Article Text

Download PDFPDF

Original research
Impact of fatigue on health-related quality of life and illness perception in a monocentric cohort of patients with systemic lupus erythematosus
  1. Elena Elefante1,2,
  2. Chiara Tani1,
  3. Chiara Stagnaro1,
  4. Francesco Ferro1,
  5. Alice Parma1,
  6. Linda Carli1,
  7. Viola Signorini1,
  8. Dina Zucchi1,
  9. Umberto Peta1,
  10. Adele Santoni1,
  11. Leonardo Raffaelli1 and
  12. Marta Mosca1
  1. 1Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
  2. 2Department of Medical Biotechnologies, University of Siena, Siena, Italy
  1. Correspondence to Marta Mosca; marta.mosca{at}med.unipi.it

Abstract

Background Fatigue is a very common and debilitating symptom in patients with systemic lupus erythematosus (SLE), even among those with a mild or inactive disease. The objective of this study is to define fatigue determinants and describe the impact of fatigue on health-related quality of life (HRQoL) and illness perception in a monocentric cohort of patients with SLE.

Methods This is a cross-sectional study. Adult patients with SLE were included. For each patient, demographics, medications, comorbidities, organ damage (Systemic Lupus International Collaborating Clinics Damage Index), active disease manifestations and Systemic Lupus Disease Activity Index scores were collected. It was evaluated if each patient met the definitions of remission and low disease activity. At enrolment, each patient completed the Short Form-36 (SF-36), Functional Assessment Chronic Illness Therapy-Fatigue (FACIT-F), Lupus Impact Tracker (LIT), Systemic Lupus Activity Questionnaire (SLAQ) and Brief Index of Lupus Damage (BILD). The FACIT-F questionnaire was also administered to a group of healthy controls.

Results 223 patients were included (mean age 44.9±13.2 years, median disease duration 13 years). 18.2% had an active disease, 43.5% met the definition of remission on treatment, and 11.8% had a concomitant fibromyalgia. The median FACIT-F score of our cohort was significantly lower compared with that of healthy controls (40 vs 47; p<0.001). FACIT-F scores were irrespective of age, disease duration, disease activity and damage. FACIT-F score was significantly lower in patients with fibromyalgia (p<0.01). FACIT-F scores demonstrated a significant correlation with all other patient-reported outcomes: SF-36 (r=0.53–0.77), LIT (r=−0.78), SLAQ (r=−0.72) and BILD (r=−0.28).

Conclusions Fatigue in patients with SLE has a strong negative impact on HRQoL and patient perception of the disease burden. Fatigue seems irrespective of disease activity but significantly influenced by the presence of fibromyalgia.

  • systemic lupus erythematosus
  • patient perspective
  • autoimmune diseases
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Statistics from Altmetric.com

Footnotes

  • Contributors EE contributed to the acquisition of data, and to the analysis and interpretation of data, and was in charge of writing the manuscript. CT contributed to the conception and design of the study and to the acquisition of data, was responsible for the analysis and interpretation of data, and contributed to writing the manuscript. CS, FF, AP, LC, VS, DZ, UP, AS and LR actively contributed to the acquisition of data and drafting the manuscript. MM contributed to the conception and design of the study and to the acquisition of data, was responsible for the analysis and interpretation of data, and contributed to writing the manuscript. All authors have read and approved the final version of the article.

  • Funding EE received financial support from the INTEGRATE project (European Commission, 3rd Health Programme, Proposal ID 769736) and from the University of Pisa (BIHO).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the local ethics committee ('Comitato Etico di Area Vasta Nord Ovest' (CEAVNO), committee’s reference number: 14478). Patients signed informed consent for the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.