Article Text

Download PDFPDF

Peripheral spondyloarthritis: a neglected entity—state of the art
  1. Philippe Carron1,2,
  2. Ann-Sophie De Craemer1,2 and
  3. Filip Van den Bosch1,2
  1. 1Rheumatology, University Hospital Ghent, Ghent, Belgium
  2. 2VIB Center for Inflammation Research, Ghent, Belgium
  1. Correspondence to Philippe Carron; philippe.carron{at}


Peripheral spondyloarthritis (pSpA) refers to a number of seemingly different spondyloarthritis subsets in which psoriatic arthritis (PsA) is the most common, and symptoms of arthritis, enthesitis or dactylitis predominate the clinical presentation. Although formal classification criteria for pSpA have been introduced in 2011, only a minority of epidemiological and clinical studies addressed this clinical entity as a separate disease. Moreover, research on outcome measures and treatment modalities in pSpA has been mainly focused on PsA. Subsequently, all biological treatments are off-label in patients with non-psoriatic pSpA. Its neglected status has important implications for clinical practice since the emerging group of early-diagnosed non-psoriatic pSpA patients remains poorly characterised and lacks specific treatment recommendations. This review summarises what is currently known regarding pSpA in terms of epidemiology, clinical presentation, diagnosis and therapeutic approach.

  • Spondyloarthritis
  • Anti-TNF
  • Magnetic resonance imaging
  • Rheumatoid arthritis
  • Ankylosing spondylitis

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:

View Full Text

Statistics from


  • PC and ASDC contributed equally.

  • Contributors PC and A-SDC contributed equally to this review in terms of conception and design, the acquisition, analysis and interpretation of the data. Drafting the work or revising it critically for important intellectual content was performed by FPvB.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethical approval Not applicable.

  • Data sharing statement Not applicable.

  • Provenance and peer review Commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.