Peripheral spondyloarthritis (pSpA) refers to a number of seemingly different spondyloarthritis subsets in which psoriatic arthritis (PsA) is the most common, and symptoms of arthritis, enthesitis or dactylitis predominate the clinical presentation. Although formal classification criteria for pSpA have been introduced in 2011, only a minority of epidemiological and clinical studies addressed this clinical entity as a separate disease. Moreover, research on outcome measures and treatment modalities in pSpA has been mainly focused on PsA. Subsequently, all biological treatments are off-label in patients with non-psoriatic pSpA. Its neglected status has important implications for clinical practice since the emerging group of early-diagnosed non-psoriatic pSpA patients remains poorly characterised and lacks specific treatment recommendations. This review summarises what is currently known regarding pSpA in terms of epidemiology, clinical presentation, diagnosis and therapeutic approach.
- Magnetic resonance imaging
- Rheumatoid arthritis
- Ankylosing spondylitis
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PC and ASDC contributed equally.
Contributors PC and A-SDC contributed equally to this review in terms of conception and design, the acquisition, analysis and interpretation of the data. Drafting the work or revising it critically for important intellectual content was performed by FPvB.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethical approval Not applicable.
Data sharing statement Not applicable.
Provenance and peer review Commissioned; externally peer reviewed.
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