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Is it Kawasaki shock syndrome, Kawasaki-like disease or pediatric inflammatory multisystem disease? The importance of semantic in the era of COVID-19 pandemic
  1. Isabelle Koné-Paut1 and
  2. Rolando Cimaz2
  1. 1 Service De Rhumatologie Pédiatrique, Centre De Référence Des Maladies Auto-Inflammatoires et de l’amylose inflammatoire, Hospital Bicetre, APHP and University of Paris Sud Saclay, Le Kremlin-Bicetre, France
  2. 2 Department of Clinical Sciences and Community Health, University of Milan, and ASST G. Pini, Milan, Italy
  1. Correspondence to Isabelle Kone-Paut; isabelle.kone-paut{at}aphp.fr

Abstract

A few weeks after the peak of the global 2019 novel coronavirus disease pandemic, cases of shock, multisystem inflammation and severe myocarditis have occurred in children and adolescents, generating some concerns and above all many questions. An almost immediate association raised with shock syndrome related to Kawasaki disease (KD). However, in light of bo/th experience and literature have taught us about severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, and what already known on the epidemiology of KD, we suggest here the hypothesis of a new ‘post-viral’ systemic inflammatory disease related to excessive adaptive immune response rather than a form of KD caused by SARS-COV-2. We discuss analogies and differences between the two forms.

  • Systemic vasculitis
  • Behcet Syndrome
  • Arthritis
  • Juvenile
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Footnotes

  • Contributors IK-P and RC contributed equally to the writing of the manuscript. Both revised the manuscript critically for intellectual content, approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests IK-P has received consulting fees from AbbVie, Pfizer, Roche, CHUGAI, Novartis, SOBI and Novimmune. RC has no competing interests.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement There are no data in this work.

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