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Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials
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  • Published on: 23 November 2021
    Colchicine is useful in outpatients, though not in inpatients

    I agree that the evidence shows no benefit from colchicine in hospitalized patients with covid-19. But I am puzzled by the authors' inclusion of the large, high-quality study by Tardif and colleagues, in high-risk outpatients, as a negative trial. It is true that the benefit of colchicine was not statistically significant when patients who did not have documented covid-19 were included in the analyses. But among patients with positive PCR swabs, those who received colchicine were 30% less likely to develop pneumonia and 25% less likely to wind up hospitalized or dead than those who received placebo - statistically significant in both cases.
    https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00222-8/fulltext

    Conflict of Interest:
    None declared.