PT  - JOURNAL ARTICLE
AU  - Annie Chou
AU  - John A Gonzales
AU  - Troy E Daniels
AU  - Lindsey A Criswell
AU  - Stephen C Shiboski
AU  - Caroline H Shiboski
TI  - Health-related quality of life and depression among participants in the Sjögren’s International Collaborative Clinical Alliance registry
AID  - 10.1136/rmdopen-2017-000495
DP  - 2017 Sep 01
TA  - RMD Open
PG  - e000495
VI  - 3
IP  - 2
4099  - http://rmdopen.bmj.com/content/3/2/e000495.short
4100  - http://rmdopen.bmj.com/content/3/2/e000495.full
SO  - RMD Open2017 Sep 01; 3
AB  - Objective To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren’s syndrome (SS) registry, comparing those with and without SS.Methods Cross-sectional study of participants in the Sjögren’s International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS classification criteria were used to determine disease status. HRQoL was assessed using the Short Form 12, version 2 Health Survey to derive scores for physical component summary (PCS) and mental component summary (MCS). Depression was assessed using the 9-Item Patient Health Questionnaire. Multivariate linear and logistic regression analyses were performed to identify predictors of HRQoL and depression while controlling for potential confounders.Results Among 2401 SICCA participants who had symptoms of dry eyes and dry mouth, 1051 had SS (44%) and 1350 did not (56%). After controlling for confounders, when compared with non-SS participants, those with SS had better PCS (p<0.001, β=2.43, 95% CI 1.57 to 3.29), MCS (p=0.002, β=1.37, 95% CI 0.50 to 2.23) and lower adjusted odds of depression (p<0.001, OR 0.67, 95% CI 0.55 to 0.81). Other significant predictors of HRQoL and depression included employment, country of residence and use of medication with anticholinergic effect or for management of SS-related signs and symptoms.Conclusion Our results suggest that among symptomatic patients, having a diagnosis of SS may be associated with better emotional and psychological well-being compared with patients without a diagnosis. Having a definitive diagnosis of SS may encourage patients to obtain a better understanding of their disease and have coping mechanisms in place to better manage their symptoms.