RT Journal Article
SR Electronic
T1 Health-related quality of life and depression among participants in the Sjögren’s International Collaborative Clinical Alliance registry
JF RMD Open
JO RMD Open
FD EULAR
SP e000495
DO 10.1136/rmdopen-2017-000495
VO 3
IS 2
A1 Annie Chou
A1 John A Gonzales
A1 Troy E Daniels
A1 Lindsey A Criswell
A1 Stephen C Shiboski
A1 Caroline H Shiboski
YR 2017
UL http://rmdopen.bmj.com/content/3/2/e000495.abstract
AB Objective To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren’s syndrome (SS) registry, comparing those with and without SS.Methods Cross-sectional study of participants in the Sjögren’s International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS classification criteria were used to determine disease status. HRQoL was assessed using the Short Form 12, version 2 Health Survey to derive scores for physical component summary (PCS) and mental component summary (MCS). Depression was assessed using the 9-Item Patient Health Questionnaire. Multivariate linear and logistic regression analyses were performed to identify predictors of HRQoL and depression while controlling for potential confounders.Results Among 2401 SICCA participants who had symptoms of dry eyes and dry mouth, 1051 had SS (44%) and 1350 did not (56%). After controlling for confounders, when compared with non-SS participants, those with SS had better PCS (p<0.001, β=2.43, 95% CI 1.57 to 3.29), MCS (p=0.002, β=1.37, 95% CI 0.50 to 2.23) and lower adjusted odds of depression (p<0.001, OR 0.67, 95% CI 0.55 to 0.81). Other significant predictors of HRQoL and depression included employment, country of residence and use of medication with anticholinergic effect or for management of SS-related signs and symptoms.Conclusion Our results suggest that among symptomatic patients, having a diagnosis of SS may be associated with better emotional and psychological well-being compared with patients without a diagnosis. Having a definitive diagnosis of SS may encourage patients to obtain a better understanding of their disease and have coping mechanisms in place to better manage their symptoms.