TY - JOUR T1 - Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project JF - RMD Open JO - RMD Open DO - 10.1136/rmdopen-2017-000641 VL - 4 IS - 1 SP - e000641 AU - Marian H van Beers-Tas AU - Marieke M ter Wee AU - Lilian H van Tuyl AU - Bertha Maat AU - Wijnanda Hoogland AU - Aase H Hensvold AU - Anca I Catrina AU - Erika Mosor AU - Tanja A Stamm AU - Axel Finckh AU - Delphine S Courvoisier AU - Andrew Filer AU - Ilfita Sahbudin AU - Rebecca J Stack AU - Karim Raza AU - Dirkjan van Schaardenburg Y1 - 2018/05/01 UR - http://rmdopen.bmj.com/content/4/1/e000641.abstract N2 - Objectives To describe the development and assess the psychometric properties of the novel ‘Symptoms in Persons At Risk of Rheumatoid Arthritis’ (SPARRA) questionnaire in individuals at risk of rheumatoid arthritis (RA) and to quantify their symptoms.Methods The questionnaire items were derived from a qualitative study in patients with seropositive arthralgia. The questionnaire was administered to 219 individuals at risk of RA on the basis of symptoms or autoantibody positivity: 74% rheumatoid factor and/or anticitrullinated protein antibodies positive, 26% seronegative. Validity, reliability and responsiveness were assessed. Eighteen first degree relatives (FDR) of patients with RA were used for comparison.Results Face and content validity were high. The test-retest showed good agreement and reliability (1 week and 6 months). Overall, construct validity was low to moderate, with higher values for concurrent validity, suggesting that some questions reflect symptom content not captured with regular Visual Analogue Scale pain/well-being. Responsiveness was low (small subgroup). Finally, the burden of symptoms in both seronegative and seropositive at risk individuals was high, with pain, stiffness and fatigue being the most common ones with a major impact on daily functioning. The FDR cohort (mostly healthy individuals) showed a lower burden of symptoms; however, the distribution of symptoms was similar.Conclusions The SPARRA questionnaire has good psychometric properties and can add information to currently available clinical measures in individuals at risk of RA. The studied group had a high burden and impact of symptoms. Future studies should evaluate whether SPARRA data can improve the prediction of RA in at risk individuals. ER -