PT  - JOURNAL ARTICLE
AU  - Jennifer Strouse
AU  - Brittney M Donovan
AU  - Munazza Fatima
AU  - Ruth Fernandez-Ruiz
AU  - Rebecca J Baer
AU  - Nichole Nidey
AU  - Chelsey Forbess
AU  - Gretchen Bandoli
AU  - Randi Paynter
AU  - Nisha Parikh
AU  - Laura Jeliffe-Pawlowski
AU  - Kelli K Ryckman
AU  - Namrata Singh
TI  - Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study
AID  - 10.1136/rmdopen-2018-000878
DP  - 2019 Apr 01
TA  - RMD Open
PG  - e000878
VI  - 5
IP  - 1
4099  - http://rmdopen.bmj.com/content/5/1/e000878.short
4100  - http://rmdopen.bmj.com/content/5/1/e000878.full
SO  - RMD Open2019 Apr 01; 5
AB  - Objectives Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth outcomes remains less studied to date. Our objective was to evaluate the impact of ARDs on preterm birth (PTB), congenital anomalies, low birth weight (LBW) and small for gestational age (SGA), in a large cohort of women.Methods We conducted a propensity score-matched analysis to predict ARD from a retrospective birth cohort of all live, singleton births in California occurring between 2007 and 2012. Data were derived from birth certificate records linked to hospital discharge International Classification of Diseases, ninth revision codes.Results We matched 10 244 women with a recorded ARD diagnosis (rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome, PsA); ankylosing spondylitis and juvenile idiopathic arthritis (JIA) to those without an ARD diagnosis. The adjusted OR (aOR) of PTB was increased for women with any ARD (aOR 1.93, 95% CI 1.78 to 2.10) and remained significant for those with RA, SLE, PsA and JIA. The odds of LBW and SGA were also significantly increased among women with an ARD diagnosis. ARDs were not associated with increased odds of congenital anomalies.Conclusion Consistent with prior literature, we found that women with ARDs are more likely to have PTB or deliver an SGA infant. Some reassurance is provided that an increase in congenital anomalies was not found even in this large cohort.