TY - JOUR T1 - Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome JF - RMD Open JO - RMD Open DO - 10.1136/rmdopen-2018-000885 VL - 5 IS - 1 SP - e000885 AU - Kate L Hackett AU - Kristen Davies AU - Jessica Tarn AU - Rebecca Bragg AU - Ben Hargreaves AU - Samira Miyamoto AU - Peter McMeekin AU - Sheryl Mitchell AU - Simon Bowman AU - Elizabeth J Price AU - Colin Pease AU - Paul Emery AU - Jacqueline Andrews AU - Peter Lanyon AU - John Hunter AU - Monica Gupta AU - Michele Bombardieri AU - Nurhan Sutcliffe AU - Costantino Pitzalis AU - John McLaren AU - Annie Cooper AU - Marian Regan AU - Ian Giles AU - David Isenberg AU - Saravan Vadivelu AU - David Coady AU - Bhaskar Dasgupta AU - Neil McHugh AU - Steven Young-Min AU - Robert Moots AU - Nagui Gendi AU - Mohammed Akil AU - Bridget Griffiths AU - Dennis W Lendrem AU - Wan-Fai Ng A2 - , Y1 - 2019/04/01 UR - http://rmdopen.bmj.com/content/5/1/e000885.abstract N2 - Objectives To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness.Methods From our cohort (n = 608), we identified those with comorbidities associated with fatigue, and those taking medications associated with drowsiness. We constructed dummy variables, permitting the contribution of these potentially assignable causes of fatigue to be assessed. Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables.Results Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). In addition, dryness was strongly associated with physical fatigue (p ≤ 0.0001). These effects were observed even after adjustment for comorbidities associated with fatigue or medications associated with drowsiness.Conclusions These findings support further research and clinical interventions targeting pain, dryness, depression and sleep to improve fatigue in patients with pSS.This finding is robust to both the effect of other comorbidities associated with fatigue and medications associated with drowsiness. ER -