RT Journal Article
SR Electronic
T1 Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome
JF RMD Open
JO RMD Open
FD EULAR
SP e000885
DO 10.1136/rmdopen-2018-000885
VO 5
IS 1
A1 Kate L Hackett
A1 Kristen Davies
A1 Jessica Tarn
A1 Rebecca Bragg
A1 Ben Hargreaves
A1 Samira Miyamoto
A1 Peter McMeekin
A1 Sheryl Mitchell
A1 Simon Bowman
A1 Elizabeth J Price
A1 Colin Pease
A1 Paul Emery
A1 Jacqueline Andrews
A1 Peter Lanyon
A1 John Hunter
A1 Monica Gupta
A1 Michele Bombardieri
A1 Nurhan Sutcliffe
A1 Costantino Pitzalis
A1 John McLaren
A1 Annie Cooper
A1 Marian Regan
A1 Ian Giles
A1 David Isenberg
A1 Saravan Vadivelu
A1 David Coady
A1 Bhaskar Dasgupta
A1 Neil McHugh
A1 Steven Young-Min
A1 Robert Moots
A1 Nagui Gendi
A1 Mohammed Akil
A1 Bridget Griffiths
A1 Dennis W Lendrem
A1 Wan-Fai Ng
A1 ,
YR 2019
UL http://rmdopen.bmj.com/content/5/1/e000885.abstract
AB Objectives To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness.Methods From our cohort (n = 608), we identified those with comorbidities associated with fatigue, and those taking medications associated with drowsiness. We constructed dummy variables, permitting the contribution of these potentially assignable causes of fatigue to be assessed. Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables.Results Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). In addition, dryness was strongly associated with physical fatigue (p ≤ 0.0001). These effects were observed even after adjustment for comorbidities associated with fatigue or medications associated with drowsiness.Conclusions These findings support further research and clinical interventions targeting pain, dryness, depression and sleep to improve fatigue in patients with pSS.This finding is robust to both the effect of other comorbidities associated with fatigue and medications associated with drowsiness.