PT  - JOURNAL ARTICLE
AU  - Backström, Maria
AU  - Tynjälä, Pirjo
AU  - Aalto, Kristiina
AU  - Grönlund, Minna-Maija
AU  - Ylijoki, Heikki
AU  - Putto-Laurila, Anne
AU  - Kärki, Johanna
AU  - Keskitalo, Paula
AU  - Sard, Sirja
AU  - Pohjankoski, Heini
AU  - Hietanen, Maiju
AU  - Witter, Silke
AU  - Lehto, Helena
AU  - Löyttyniemi, Eliisa
AU  - Vähäsalo, Paula
TI  - Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis
AID  - 10.1136/rmdopen-2018-000888
DP  - 2019 Apr 01
TA  - RMD Open
PG  - e000888
VI  - 5
IP  - 1
4099  - http://rmdopen.bmj.com/content/5/1/e000888.short
4100  - http://rmdopen.bmj.com/content/5/1/e000888.full
SO  - RMD Open2019 Apr 01; 5
AB  - Objectives To validate cut-offs of the Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) and to compare them with other patient cohorts.Methods In a national multicentre study, cross-sectional data on recent visits of 337 non-systemic patients with juvenile idiopathic arthritis (JIA) were collected from nine paediatric outpatient units. The cut-offs were tested with receiver operating characteristic curve-based methods, and too high, too low and correct classification rates (CCRs) were calculated.Results Our earlier presented JADAS10 cut-offs seemed feasible based on the CCRs, but the cut-off values between low disease activity (LDA) and moderate disease activity (MDA) were adjusted. When JADAS10 cut-offs for clinically inactive disease (CID) were increased to 1.5 for patients with oligoarticular disease and 2.7 for patients with polyarticular disease, as recently suggested in a large multinational register study, altogether 11 patients classified as CID by the cut-off had one active joint. We suggest JADAS10 cut-off values for oligoarticular/polyarticular disease to be in CID: 0.0–0.5/0.0–0.7, LDA: 0.6–3.8/0.8–5.1 and MDA: >3.8/5.1. Suitable cJADAS10 cut-offs are the same as JADAS10 cut-offs in oligoarticular disease. In polyarticular disease, cJADAS10 cut-offs are 0–0.7 for CID, 0.8–5.0 for LDA and >5.0 for MDA.Conclusion International consensus on JADAS cut-off values is needed, and such a cut-off for CID should preferably exclude patients with active joints in the CID group.