@article {Abbarae001033, author = {Salam Abbara and Raphaele Seror and Julien Henry and Pascale Chretien and Aude Gleizes and Salima Hacein-Bey-Abina and Xavier Mariette and Gaetane Nocturne}, title = {Anti-RNP positivity in primary Sj{\"o}gren{\textquoteright}s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement}, volume = {5}, number = {2}, elocation-id = {e001033}, year = {2019}, doi = {10.1136/rmdopen-2019-001033}, publisher = {BMJ Specialist Journals}, abstract = {Objectives To describe and compare the clinical and biological characteristics of subjects with primary Sj{\"o}gren{\textquoteright}s syndrome (pSS) with and without anti-RNP antibodies.Methods Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.Results Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sj{\"o}gren{\textquoteright}s syndrome disease activity index at inclusion (8.0 vs 3.0, p\<0.01), more frequently constitutional symptoms (14.3\% vs 0.01\%, p\<0.01), myositis (19.0\% vs 2.3\%, p\<0.01) and pulmonary (19.0\% vs 5.7\%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p\<0.01), more frequently anti-SSA antibodies (90.5\% vs 67.1\%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score >=1 (66.7\% vs 85.5\%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.Conclusion Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.}, URL = {https://rmdopen.bmj.com/content/5/2/e001033}, eprint = {https://rmdopen.bmj.com/content/5/2/e001033.full.pdf}, journal = {RMD Open} }