PT - JOURNAL ARTICLE AU - Guillermo J Pons-Estel AU - Manuel Francisco Ugarte-Gil AU - Guillermina B Harvey AU - Daniel Wojdyla AU - Rosana Quintana AU - Verónica Saurit AU - Enrique R Soriano AU - Eloisa Bonfa AU - Loreto Massardo AU - Mario Cardiel AU - Luis M Vila AU - Russell Griffin AU - Bernardo A Pons-Estel AU - Graciela S Alarcón ED - , TI - Applying the 2019 EULAR/ACR lupus criteria to patients from an established cohort: a Latin American perspective AID - 10.1136/rmdopen-2019-001097 DP - 2020 Jan 01 TA - RMD Open PG - e001097 VI - 6 IP - 1 4099 - http://rmdopen.bmj.com/content/6/1/e001097.short 4100 - http://rmdopen.bmj.com/content/6/1/e001097.full SO - RMD Open2020 Jan 01; 6 AB - Objective To evaluate the performance of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) criteria in terms of earlier patients’ classification in comparison to the 1982/1997 ACR or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria.Materials and methods Patients from a Latin America, multiethnic, multicentre cohort, where SLE was defined using the physicians’ diagnosis, were included. To calculate the sensitivity of the 2019 EULAR/ACR criteria, the 1982/1997 ACR criteria were considered the gold standard. Additionally, comparison of the 1982/1997 ACR criteria and the 2012 SLICC criteria with the 2019 EULAR/ACR criteria was performed.Results The sensitivity of the 2019 EULAR/ACR criteria when compared with the 1982/1997 ACR criteria as the gold standard was 91.3%. This new set of criteria allowed an earlier SLE patient classification in 7.4% (mean 0.67 years) and 0.6% (mean 1.47 years) than the 1982/1997 ACR and the 2012 SLICC criteria, respectively. Patients accruing the 2019 EULAR/ACR earlier than the 1982/1997 ACR criteria were more likely to have high anti-dsDNA titres; those accruing them later were less likely to have mucocutaneous and joint manifestations; this was not observed when comparing them with the 2012 SLICC criteria.Conclusions The 2019 EULAR/ACR criteria classified earlier only a small proportion of Latin America patients than with the two other criteria sets in real-life clinical practice scenarios. Further studies in different patient populations are needed before these new criteria are adopted worldwide.