RT Journal Article
SR Electronic
T1 Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis
JF RMD Open
JO RMD Open
FD EULAR
SP e001265
DO 10.1136/rmdopen-2020-001265
VO 6
IS 2
A1 Ida K Haugen
A1 David T Felson
A1 Abhishek Abhishek
A1 Francis Berenbaum
A1 Sita Bierma-Zeinstra
A1 Tove Borgen
A1 Gabriel Herrero Beaumont
A1 Mariko Ishimori
A1 Helgi Jonsson
A1 Féline PB Kroon
A1 Emmanuel Maheu
A1 Roberta Ramonda
A1 Valentin Ritschl
A1 Tanja A Stamm
A1 Desirée van der Heijde
A1 Ruth Wittoek
A1 Elsie Greibrokk
A1 Wilma Smeets
A1 Margreet Kloppenburg
YR 2020
UL http://rmdopen.bmj.com/content/6/2/e001265.abstract
AB Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA.Methods In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Discrimination between groups was assessed by calculating the area under receiver operating curves (AUC).Results Strong associations with hand OA were observed for radiographic osteophytes (OR = 1.62, 95% CI 1.40 to 1.88) and joint space narrowing (JSN) (OR = 1.57, 95% CI 1.36 to 1.82) in the distal interphalangeal (DIP) joints with excellent discrimination (AUC = 0.82 for both). For osteophytes and JSN, we found acceptable discrimination between groups in the proximal interphalangeal joints (AUC = 0.77 and 0.78, respectively), but poorer discrimination in the first carpometacarpal joints (AUC = 0.67 and 0.63, respectively). Painful DIP joints were associated with hand OA, but were less able to discriminate between groups (AUC = 0.67). Age and family history of OA were positively associated with hand OA, whereas negative associations were found for pain, stiffness and soft tissue swelling in metacarpophalangeal joints, pain and marginal erosions in wrists, longer morning stiffness, inflammatory biomarkers and autoantibodies.Conclusions Differences in symptoms, clinical findings, radiographic changes and laboratory tests were found in patients with hand OA versus controls. Radiographic OA features, especially in DIP joints, were best suited to discriminate between groups.