PT  - JOURNAL ARTICLE
AU  - Rim Bourguiba
AU  - Maeva Kyheng
AU  - Isabelle Koné-Paut
AU  - Diane Rouzaud
AU  - Jerome Avouac
AU  - Mathilde Devaux
AU  - Nassim Ait Abdallah
AU  - Bruno Fautrel
AU  - Nicole Ferreira-Maldent
AU  - Vincent Langlois
AU  - Emmanuel Ledoult
AU  - Hubert Nielly
AU  - Viviane Queyrel
AU  - Jérémie Sellam
AU  - Nathalie Tieulie
AU  - Pascal Chazerain
AU  - Philippe Evon
AU  - Julien Labreuche
AU  - Léa Savey
AU  - Veronique Hentgen
AU  - Gilles Grateau
AU  - Sophie Georgin-lavialle
ED  - ,
TI  - COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI – the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases
AID  - 10.1136/rmdopen-2021-002063
DP  - 2022 May 01
TA  - RMD Open
PG  - e002063
VI  - 8
IP  - 1
4099  - http://rmdopen.bmj.com/content/8/1/e002063.short
4100  - http://rmdopen.bmj.com/content/8/1/e002063.full
SO  - RMD Open2022 May 01; 8
AB  - Objective There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared.Methods A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days.Results We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet’ disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted.Conclusion As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.