RT Journal Article
SR Electronic
T1 COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI – the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases
JF RMD Open
JO RMD Open
FD EULAR
SP e002063
DO 10.1136/rmdopen-2021-002063
VO 8
IS 1
A1 Rim Bourguiba
A1 Maeva Kyheng
A1 Isabelle Koné-Paut
A1 Diane Rouzaud
A1 Jerome Avouac
A1 Mathilde Devaux
A1 Nassim Ait Abdallah
A1 Bruno Fautrel
A1 Nicole Ferreira-Maldent
A1 Vincent Langlois
A1 Emmanuel Ledoult
A1 Hubert Nielly
A1 Viviane Queyrel
A1 Jérémie Sellam
A1 Nathalie Tieulie
A1 Pascal Chazerain
A1 Philippe Evon
A1 Julien Labreuche
A1 Léa Savey
A1 Veronique Hentgen
A1 Gilles Grateau
A1 Sophie Georgin-lavialle
A1 ,
YR 2022
UL http://rmdopen.bmj.com/content/8/1/e002063.abstract
AB Objective There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared.Methods A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days.Results We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet’ disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted.Conclusion As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.