TY - JOUR T1 - How do multiple long-term conditions impact on the cost-of-illness in early rheumatoid arthritis? JF - RMD Open JO - RMD Open DO - 10.1136/rmdopen-2022-002454 VL - 8 IS - 2 SP - e002454 AU - Ping-Hsuan Hsieh AU - Claudia Geue AU - Olivia Wu AU - Emma McIntosh AU - Stefan Siebert Y1 - 2022/09/01 UR - http://rmdopen.bmj.com/content/8/2/e002454.abstract N2 - Objective Multiple long-term conditions (MLTCs) are prevalent in rheumatoid arthritis (RA) and associated with worse outcomes and greater economic burden. However, little is known about the impact of MLTCs on the cost-of-illness (COI) in early RA, including direct and indirect costs. The objective of this study was to quantify this impact on COI.Methods The Scottish Early Rheumatoid Arthritis study is a national cohort of adults with new-onset RA. Direct costs were estimated applying relevant unit costs to health resource utilisation; indirect costs were measured by productivity loss due to health conditions. Two-part models were used, adjusting for age, gender, baseline functional disability and health-related quality of life. The Charlson Comorbidity Index score was calculated using ICD-10 diagnoses. Individuals were defined as ‘RA alone’, ‘RA plus LTC’ and ‘RA plus MLTCs’ according to the number of coexisting LTCs.Results Data were available for 818 participants. Average annualised direct costs incurred by people with early RA plus MLTCs (£4444; 95% CI £3100 to £6371) were twice as, and almost five times higher than, those with a single LTC (£2184; 95% CI £1596 to £2997) and those without LTC (£919; 95% CI £694 to £1218), respectively. Indirect costs incurred by RA plus MLTCs (£842; 95% CI £377to £1521) were 3.1 times higher than RA alone (£530; 95% CI £273to £854). The relative proportion of direct costs increased with LTC category, ranging from 77.2% to 84.1%. In addition to increased costs with LTCs, costs also increased with age and were higher for men regardless of LTC category.Conclusions MLTCs impact on COI early in the course of RA. The presence of LTCs is associated with significant increases in both direct and indirect costs among people with early RA.Data are available on reasonable request. The SERA outcome data are stored and managed by the University of Glasgow and are available for analysis by bona fides external researchers. Applications to access the resources are reviewed by the SERA Access Committee and application details are available on the SCAR website (www.scarnetwork.org). ER -