TY - JOUR T1 - Thrombotic and immunological phenomena following COVID-19 vaccination: experience from a case series JF - RMD Open JO - RMD Open DO - 10.1136/rmdopen-2022-002841 VL - 9 IS - 1 SP - e002841 AU - Chathurika Lakmini Dandeniya AU - Theekshana Kavinda Premathilake Y1 - 2023/02/01 UR - http://rmdopen.bmj.com/content/9/1/e002841.abstract N2 - Vaccination has undoubtedly reduced COVID-19-related mortality globally.1 However, being a new vaccine with limited clinical trial experience, postmarketing data are important to establish safety and side effect profile. Thrombotic and autoimmune phenomena have been reported globally following vaccination.2 A multicentre study in Sri Lanka failed to identify any significant adverse events following AZD1222 (ChAdOx1) first dose in Sri Lanka.3 However, we present our experience with a case series identifying serious thrombotic and autoimmune complications following different types of COVID-19 vaccination in Sri Lanka.We collected data from patients who presented to Teaching Hospital Peradeniya with thrombotic and/or immunological phenomena following COVID-19 vaccination from September 2021 to March 2022. Being a tertiary care hospital affiliated to a national university, the referred patients were from across the country. A causal relationship was assumed in patients in whom the symptoms appeared within 6 weeks of vaccination, without similar symptoms preceding the vaccination. Active COVID-19 infection was excluded in all patients with thrombotic complications and in all patients requiring hospital admission due to other symptoms. In patients presenting to outpatient rheumatology services, five had … ER -