PT  - JOURNAL ARTICLE
AU  - Yeonghee Eun
AU  - Jiwon Hwang
AU  - Gi Hyeon Seo
AU  - Joong Kyong Ahn
TI  - Risk of cancer in Korean patients with psoriatic arthritis: a nationwide population-based cohort study
AID  - 10.1136/rmdopen-2022-002874
DP  - 2023 Mar 01
TA  - RMD Open
PG  - e002874
VI  - 9
IP  - 1
4099  - http://rmdopen.bmj.com/content/9/1/e002874.short
4100  - http://rmdopen.bmj.com/content/9/1/e002874.full
SO  - RMD Open2023 Mar 01; 9
AB  - Objective While many studies on the increased risk of cancer in patients with psoriasis are available, data on the risk of cancer in patients with psoriatic arthritis (PsA) are still scarce. We assessed the risk of cancer in patients with PsA in a nationwide population-based cohort in Korea.Methods From 2010 to June 2021, patients newly diagnosed with PsA and 1:10 age-matched and sex-matched controls were included in this study. The outcome was the incidence of overall and specific cancers.Results Total 162 cancers occurred in 4688 PsA patients (incidence rate 83.2 (95% CI 70.8 to 97.0) per 10 000 person-years) and 1307 cancers occurred in 46 880 controls (incidence rate 66.9 (95% CI 63.3 to 70.6) per 10 000 person-years). The adjusted HR (aHR) of overall cancer in PsA patients was 1.20 (95% CI 1.02 to 1.41). However, this significance disappeared when non-melanoma skin cancer (NMSC) was excluded (aHR 1.16, 95% CI 0.98 to 1.37). Among specific cancers, the risk of NMSC (aHR 3.64 (95% CI 1.61 to 8.23)), lymphoma (aHR 2.63 (95% CI 1.30 to 5.30)) and thyroid cancer (aHR 1.83 (95% CI 1.18 to 2.85)) was higher in patients with PsA than in controls.Conclusion The risk of overall cancer was higher in patients with PsA than in the general population. Patients with PsA had increased risks of NMSC, lymphoma and thyroid cancer compared with the general population. Our findings suggest a need to conduct cancer screening by a detailed history and comprehensive clinical examination in patients with PsA.Data are available on reasonable request and with permission of HIRA. The data that support the findings of this study are available from HIRA. Restrictions apply to the availability ofthese data, which were used under licence for this study.