Frequency of erosions, BME, synovitis and tenosynovitis in symptom-free persons
| First author, year of publication | N=healthy | Uni/bilateral | Erosions (%) | BME (%) | Synovitis (%) | Tenosynovitis (%) |
|---|---|---|---|---|---|---|
| Scored without a validated method | ||||||
| Wrist+MCP | ||||||
| Nakahara et al, 199611 | 10 | NP | NP | 0.0 | 0.0 | 0.0 |
| Lindegaard et al, 200112 | 3 | Unilateral | 0.0 | NP | NP | NP |
| Yoshioka et al, 200613 | 13 (+PIP) | Bilateral | 0.0 | NP | 0.0 | 0.0 |
| Offidani et al, 199814 | 12 (+IP) | NP | 0.0 | NP | 0.0 | 0.0 |
| Wrist | ||||||
| Beltran et al, 198715 | 6 | NP | 0.0 | NP | 0.0 | 0.0 |
| Jorgensen et al, 199316 | 4 | NP | 0.0 | NP | 0.0 | 0.0 |
| Yanagawa et al, 199317 | 10 | NP | NP | NP | 0.0 | NP |
| Østergaard et al, 199518 | 3 | NP | NP | NP | 0.0 | NP |
| Tonolli-Serabian et al, 199619 | 10 | Bilateral | 0.0 | NP | 0.0 | NP |
| Pierre-Jerome et al, 199720 | 42 | Bilateral | 35.7%* | 0.0 | 4.8 | Fl: 9.5 Ext: 7.1 |
| Valeri et al, 200121 | 12 | Bilateral | NP | NP | NP | 0.0 |
| Partik et al, 200222 | 18 | NP | NP | 0.0 | 44.4 | NP |
| Robertson et al, 200623 | 30 | Unilateral | NP | 13.3% | NP | NP |
| MCP | ||||||
| McGonagle et al, 199924 | 31 | Unilateral | 25.8 | 9.7 | NP | NP |
| Klarlund et al, 199925 | 3 | Unilateral | 0.0 | NP | NP | NP |
| Vlychou et al, 201326 | 5 (+PIP, DIP) | Unilateral | 0.0 | 0.0 | 0.0 | 0.0 |
| Scored according to RAMRIS | ||||||
| Wrist+MCP (2–5) | ||||||
| Brown et al, 200629 | 17 | Unilateral | NP | 0.0 | 17.6 | 5.9 |
| Ejbjerg et al, 200430 | 28 | Unilateral | NP | 0.0 | 32.1 | NP |
| Olech et al, 201031 | 40 | Bilateral | 65.0 | 17.5 | 42.5 | NP |
| Parodi et al, 200632 | 23 (+PIP) | Bilateral | 26.0 | 8.7% | NP | Fl: 17.4 Ext: 4.3 |
| Ejbjerg et al, 200533 | 9 (+MTP) | Bilateral | 55.6 | NP | NP | NP |
| Combined data29 30 | 0/45 | Unilateral | BME mean 0% (95% CI 0.0% to 6.8%) | |||
| Combined data29 30 | 12/45 | Unilateral | Synovitis mean 26.7% (95% CI 15.8% to 41.2%) | |||
| Wrist | ||||||
| Cimmino et al, 201135 | 13 | Bilateral | 30.8 | 30.8 | 0.0 | 30.8 |
| Palosaari et al, 200936 | 31 | Bilateral | 45.2 | NP | 60.0% | NP |
| Døhn et al, 200837 | 4 | Unilateral | 25.0 | NP | NP | NP |
| Duer-Jensen et al, 2011†34 | 24 | Unilateral | 45.8 | 4.5 | 81.8 | 0.0% |
| Xie et al,2008‡27 | 14 Age 25±5 | Unilateral | 0.0 | 0.0 | 0.0 | NP |
| 27 Age 62±7 | Unilateral | 88.9 | 33.3 | 3.7 | NP | |
| Combined data35 36 | 18/44 | Bilateral | Erosions mean 40.9% (95% CI 27.7% to 55.6%) | |||
| Combined data27 34 37 | 36/69 | Unilateral | Erosions mean 52.2% (95% CI 40.6% to 63.5%) | |||
| Combined data27 34 | 10/63§ | Unilateral | BME mean 15.9% (95% CI 8.7% to 27.0%) | |||
| MCP (2–5) | ||||||
| Døhn et al, 200638 | 4 | Unilateral | 0.0 | NP | NP | NP |
| Tan et al, 200339 | 28 | Unilateral | 32.1 | NP | NP | NP |
| Miese et al, 201240 | 13 MCP 2&3 | Unilateral | NP | 0.0 | 0.0 | NP |
| Duer-Jensen et al, 2011†34 | 24 | Unilateral | 45.8 | 4.5 | 45.5 | 0.0 |
| Xie et al,2008‡27 | 14 Age 25±5 | Unilateral | 0.0 | 14.3 | 0.0 | NP |
| 27 Age 62±7 | Unilateral | 44.4 | 11.1 | 14.8 | NP | |
| Combined data27 34 38 39 | 32/97 | Unilateral | Erosions mean 33.0% (95% CI 24.4% to 42.9%) | |||
| Combined data27 34 | 6/63§ | Unilateral | BME mean 9.5% (95% CI 4.1% to 19.6%) | |||
0% is noted when no erosions are found or an abnormality is described in the patient group and the healthy control group is only described as ‘no abnormalities’ with no further specification.
Bolt=studies in which contrast was used to score synovitis and tenosynovitis.
*Contradicting data in original article, with 35.7% erosions in the table and 14.3% erosions in the text.
†Same study.
‡Same study.
§Duer-Jensen only assessed 22 patients for BME.
DIP, distal interphalangeal joint; Ext, extensor tendons; Fl, flexor tendons; IP, interphalangeal joint; MCP, metacarpophalangeal joints; MTP, metatarsophalangeal; NP,Not provided; PIP, proximal interphalangeal joint.