Patient counts, event counts and unadjusted incidence rates
| Exposure categories | Description* | Number of patients | Total patient- years (×100) | Cardiovascular events/100 patient- years of exposure |
|---|---|---|---|---|
| Exposure to anti-TNF | Anti-TNF use, with possible use of MTX or other DMARDs | 40 717 | 768.9 | 1.7 |
| Exposure to MTX | MTX use with possible use of other DMARDs, but no anti-TNF | 46 681 | 230.7 | 2.0 |
| Exposure to other DMARDs | Use of other DMARDs, without use of MTX or anti-TNF | 26 279 | 129.2 | 2.7 |
*Defined hierarchically as in Greenberg et al.29 ,40
DMARD, disease-modifying antirheumatic drug; MTX, methotrexate; TNF, tumour necrosis factor.