Domain	Activity level	Description
CNS Rate as ‘No activity’ stable long-lasting features related to damage or CNS involvement not related to the disease	No=0	Absence of currently active CNS involvement
	Moderate=10	Moderately active CNS features, such as cranial nerve involvement of central origin, optic neuritis or multiple sclerosis-like syndrome with symptoms restricted to pure sensory impairment or proven cognitive impairment
	High=15	Highly active CNS features, such as cerebral vasculitis with cerebrovascular accident or transient ischaemic attack, seizures, transverse myelitis, lymphocytic meningitis, multiple sclerosis-like syndrome with motor deficit