Table 1

Systematic review of 21 studies of ultrasonography for diagnosis of CPPD

Study	Diagnosis of CPPD	CPPD cohort size/ comparator cohort size	Primary disease studied	Design	QUADAS scale (/1 4)	Assessment comparator (imaging or other)
Foldes 19	X-rays (Resnick)	21/19	CPPD/OA	P, C	8.5	X-ray
Filippucci et al15	McCarty criteria	48/84	CPPD/ORD	P, C	12.5	ND
Filippou et al16	CPPD synovial crystals	15/28	CPPD/OA	P, C	12.5	ND
Ellabban et al17	CPPD synovial crystals	38/22	CPPD/gout and HA	P, C	12.5	X-ray
Falsetti et al18	McCarty criteria	57/100	CPPD/OA+H	P, C	10.5	X-ray, CE
Gutierrez et al20	CPPD synovial crystals	74/83	CPPD/ORD	P, C	13	X-ray, CE
Ellabban et al21	McCarty criteria	38/22	CPPD/OA	P, C	10.5	X-ray, CE
Filippou et al22	CPPD meniscal crystals	3/3	CPPD/OA	P, C	10	Histology
Frediani et al7	CPPD synovial crystals	11/13	CPPD/OA	P, D	11	X-ray
Contant et al23	CPPD synovial crystals	30/36	CPPD/ORD	P, C	13.5	X-ray
Juge et al24	CPPD synovial crystals	16/16	CPPD/ORD	P, C	13	X-ray
Catay et al26	CPPD synovial crystals	15/60	CPPD/ORD	P, C	13	X-ray, CE
Filippou et al8	CPPD meniscal crystals	3/3	CPPD/OA	P, D	13	Histology
Filippucci et al9	McCarty criteria	46/39	CPPD/gout	P, D	11	CE
Filippucci et al10	McCarty criteria	70/30	CPPD/gout	P, D	9.5	CE
Coari et al11	McCarty criteria	28/46	CPPD/ND	P, D	9.5	X-ray
Filippou et al12	CPPD synovial crystals	42/0	CPPD	P, D	11	X-ray
Grassi et al13	CPPD synovial crystals	34/26	CPPD/gout	P, D	8.5	ND
Filippou et al25	CPPD meniscal crystals	25/16	CPPD/OA	P, C	11.5	Histology
Ciapetti et al14	CPPD synovial crystals	42/0	CPPD	P, D	8.5	ND
Barskova et al5	McCarty criteria	25/0	CPPD	P, C	11	X-ray, CT scan

C, comparative; CE, clinical examination; CPPD, calcium pyrophosphate deposition; D, descriptive; H, healthy; HA, hydroxyapatite; ND, not defined; OA, osteoarthritis; ORD, other rheumatic disease; P, prospective.