Comparison of the association of the HLA-DRB1 alleles and ACPA presence between the classifications of HLA-DRB1 alleles
| ESPOIR | EAC | Meta-analysis | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Acid–base | ||||||
| BB | 4.62 (3.16 to 6.75) | <0.001 | 3.63 (2.52 to 5.23) | <0.001 | 4.08 (3.14 to 5.31) | <0.001 |
| BN | 1.14 (0.83 to 1.57) | 0.4 | 1.15 (0.83 to 1.59) | 0.4 | 1.14 (0.91 to 1.44) | 0.2 |
| A | 0.37 (0.25 to 0.56) | <0.001 | 0.37 (0.24 to 0.57) | <0.001 | 0.37 (0.28 to 0.50) | <0.001 |
| NN and X | 0.39 (0.27 to 0.55) | <0.001 | 0.49 (0.34 to 0.70) | <0.001 | 0.43 (0.34 to 0.56) | <0.001 |
| De Vries | ||||||
| SE | 4.42 (3.10 to 6.33) | <0.001 | 5.00 (3.50 to 7.14) | <0.001 | 4.69 (3.66 to 6.01) | <0.001 |
| N | 0.36 (0.26 to 0.51) | <0.001 | 0.49 (0.36 to 0.69) | <0.001 | 0.42 (0.34 to 0.53) | <0.001 |
| P | 0.61 (0.44 to 0.85) | 0.003 | 0.45 (0.32 to 0.63) | <0.001 | 0.53 (0.42 to 0.67) | <0.001 |
| Mattey | ||||||
| SE | 4.42 (3.10 to 6.33) | <0.001 | 5.00 (3.50 to 7.14) | <0.001 | 4.69 (3.66 to 6.01) | <0.001 |
| D70− | 0.46 (0.32 to 0.65) | <0.001 | 0.59 (0.43 to 0.82) | 0002 | 0.55 (0.43 to 0.69) | <0.001 |
| D70+ | 0.51 (0.36 to 0.71) | <0.001 | 0.43 (0.31 to 0.60) | <0001 | 0.44 (0.35 to 0.56) | <0.001 |
| Du Montcel | ||||||
| S1 | 0.53 (0.38 to 0.75) | <0.001 | 0.55 (0.39 to 0.76) | <0.001 | 0.56 (0.44 to 0.72) | <0.001 |
| S2 | 3.42 (2.29 to 5.14) | <0.001 | 3.09 (2.15 to 4.45) | <0.001 | 3.24 (2.49 to 4.23) | <0.001 |
| S3D | 0.66 (0.45 to 0.95) | 0.02 | 0.55 (0.35 to 0.84) | 0.006 | 0.61 (0.46 to 0.80) | <0.001 |
| S3P | 2.67 (1.89 to 3.80) | <0.001 | 3.21 (2.26 to 4.58) | <0.001 | 2.88 (2.26 to 3.66) | <0.001 |
| X | 0.37 (0.27 to 0.53) | <0.001 | 0.55 (0.40 to 0.76) | <0.001 | 0.45 (0.36 to 0.57) | <0.001 |
| Reviron | ||||||
| SE | 4.42 (3.10 to 6.33) | <0.001 | 5.00 (3.50 to 7.14) | <0.001 | 4.69 (3.66 to 6.01) | <0.001 |
| XP4P | 0.57 (0.41 to 0.79) | <0.001 | 0.59 (0.43 to 0.83) | 0.002 | 0.58 (0.46 to 0.73) | <0.001 |
| XP4N | 0.44 (0.31 to 0.61) | <0.001 | 0.43 (0.31 to 0.60) | <0.001 | 0.43 (0.34 to 0.55) | <0.001 |
95% CI.
ACPA, anticitrullinated peptide antibody; BB, allele group containing basic AA at positions 13, 70 and 71; BN, allele group containing either a basic amino acid at position 13 and a neutral or acid and basic amino acid at positions 70 and 71 or a neutral amino acid at position 13 and a basic amino acid at positions 70 and 71; A, allele group containing acid amino acids at positions 70 and 71; NN, allele group with a neutral amino acid at position 13 and either a basic and an acidic amino acid at positions 70 and 71 or two neutral amino acids at positions 70 and 71; X, allele group not containing RAA sequence at positions 72–74; N, allele group not containing an isoleucine at position 67; P, allele group containing an isoleucine at position 67; SE, shared epitope; D70−, allele group not containing an aspartic acid at position 70; D70+, allele group containing an aspartic acid at position 70; XP4p, fourth pocket positively charged; XP4n, fourth pocket negatively or non-charged.