Comparison of MTX rates of adherence across studies
| Study | QA score | Quality rating | Adherence definition | Adherence is primary outcome? | Data on predictors of adherence? | Data on adherence and outcomes? | N | MTX adherence rate | 95% CI/SD |
|---|---|---|---|---|---|---|---|---|---|
| MEMS | |||||||||
| de Klerk et al22 | 12 | Low | Per cent of adherence (ratio) | Yes | Yes | No | 23 | 107% | 98 to 117 |
| Waimann et al30 | 15 | High | Per cent of adherence (ratio) | Yes | Yes | Yes | 76 | 63% | 20% |
| Pharmacy refill | |||||||||
| Harley et al21 | 8 | High | Per cent of adherent (MPR ≥80%) | Yes | No | No | 1668 | 64% | 24 to 102 |
| Grijalva et al23 | 15 | High | Per cent of adherence (MPR) | Yes | Yes | No | 2933 | 80% | NP |
| Grijalva et al25 | 9 | High | Per cent of adherence (MPR) | No | No | No | NP | 59% | 31 to 82 |
| de Thurah et al26 | 14 | High | Per cent of non-adherence (CMG) | Yes | Yes | No | 941 | 12% | 1113 |
| Cannon et al28 | 15 | High | Per cent of adherent (MPR ≥80%) | Yes | No | Yes | 384 | 84% | NP |
| Self-report | |||||||||
| Contreras-Yanez et al24 | 11 | Low | Per cent of adherent (7-day DRR ≥80%) | Yes | Yes | Yes | 10 | 78% | NP |
| de Thurah et al27 | 14 | High | Per cent of non-adherent (CQ-R ≤25th centile) | Yes | Yes | No | 85 65 | BL 23% 9 mo 23% | NP NP |
| Salt and Frazier29 | 9 | Low | Per cent of adherent (MARS ≥39) | Yes | Yes | No | 77 | 92% | NP |
9 mo, 9 months; BL, baseline; CMG, continuous medication gap; CQ-R, Compliance Questionnaire-Rheumatology; DRR, Drug Record Registry; MARS, Medication Adherence Revised Scale; MEMS, Medication Event Monitoring System; MPR, medication possession ratio; MTX, methotrexate; NP, information not presented.