Pearson correlations of methotrexate pharmacokinetic parameters with immune parameters and laboratory values in patients with rheumatoid arthritis
| IL-1B serum | IL-1B supernatant | IL-2 | IL-2 supernatants | IL-6 serum | IL-8 serum | Serum | WCC | Platelets | CD4 | CD8 | CD4, CD8 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | r=0.23 p=0.045 | r=−0.41 p=0.028 | ||||||||||
| CMAX | r=−0.17 p=0.016 | r=−0.17 p=0.017 | r=0.34 p=0.072 | r=−0.48 p=0.009 | r=−0.32 p=0.09 | |||||||
| TMAX | ||||||||||||
| t* | ||||||||||||
| Weekly MTX dose(mean) | r=0.20 p=0.038 | r=−0.30 p=0.002 |
*t=Bioavailability.
AUC, area under the curve; CMax, maximal serum concentration; IL, interleukin; MTX, methotrexate; TMax, time from dosing to maximal serum concentration; WCC, white cell count.