Cytokine levels in patients with pSS and healthy controls
| Cytokine | Controls (n=28) | Cases with pSS (n=159) | p Value |
|---|---|---|---|
| CD54 | 41882.42 31954.3, 68077.5 | 47915.84 36203.1, 76537.1 | 0.2599 |
| RANTES | 19117.12 13203.8, 28251.3 | 21472.56 15722.97, 28255.1 | 0.1643 |
| CD106 | 67543.20 51824.4, 75985.4 | 80921.58 57934.1, 96570.5 | 0.0042 |
| IL-8 | 37378.14 11075.6, 311730.2 | 35623.48 10596.6, 374424.3 | 0.6929 |
| IP-10 | 110.24 75.0, 167.4 | 342.38 226.2, 540.5 | <0.0001 |
| IF | 1.34 0.8, 2.2 | 1.48 0.7, 4.5 | 0.1659 |
| IL-17 | 1.32 0.4, 2.0 | 3.28 1.3, 47.0 | <0.0001 |
| IL-21 | 45.33 30.6, 63.4 | 71.71 40.0, 782.8 | 0.0006 |
| MIP1α | 5.85 1.7, 101.4 | 99.52 6.9, 219.3 | <0.0001 |
| TNF-α | 0.08 0.0, 0.1 | 7.00 0.1, 27.1 | <0.0001 |
| LT-α | 0.33 0.2, 0.6 | 2.5 0.5, 13.0 | <0.0001 |
| P-selectin | 7385.86 5802.8, 8894.1 | 8212.16 5148.01, 11983.12 | 0.3287 |
| MCP-1 | 131.62 95.3, 221.7 | 170.42 121.8, 318.2 | 0.1061 |
| E-selectin | 2515.06 1691.2, 3588.5 | 2862.34 1992.0, 4241.0 | 0.3213 |
| MIP1β | 78.96 27.0, 136.5 | 178.40 97.3, 333.8 | <0.0001 |
| IFN-γ | 1.90 0.5, 3.2 | 2.97 1.4, 10.6 | 0.0018 |
| MIG | 125.90 84.5, 244.0 | 986.32 458.4, 2593.4 | <0.0001 |
| CD40 ligand | 2838.26 1893.4, 3559.4 | 2449.40 1825.4, 3239.5 | 0.1065 |
| IL-6 | 938.18 506.7, 1537.1 | 1544.46 836.5, 2931.9 | 0.0020 |
| IL-1β | 126 45.8, 698.7 | 271.23 47.7, 738.2 | 0.3767 |
| IL-10 | 50.68 9.9, 360.0 | 490.90 129.6, 881.9 | <0.0001 |
| IL-12p70 | 16.63 8.40, 25.0 | 27.18 13.41, 206.4 | 0.0024 |
| IL-4 | 0.00 0.00, 0.00 | 0.00 0.00. 0.00 | 0.3322 |
| IL-12.IL-3p40 | 0.00 0.00, 0.00 | 0.00 0.00, 0.00 | 0.0117 |
Bold typeface indicates significance.
Generally cytokines were significantly higher in patients with pSS compared to controls. Values in table represent median and 25th, 75th centile (pmol/L).
CD, cluster of differentiation; IFN-γ, interferon-γ; IL, interleukin; IP-10, interferon-γ-induced protein-10; LT-α, lymphotoxin-α; MCP-1, monocyte chemoattractant protein-1; MIG, monokine induced by γ interferon; MIP, macrophage inflammatory protein; pSS, primary Sjögren's syndrome; RANTES, regulated on activation normal T expressed and secreted; TNF-α, tumour necrosis factor-α.