Table 1

Studies evaluating recognition and referral of early arthritis (EA) patients

Study (LoE)PopulationControlsOutcomeSensSpecPPVNPV
A. Recognition of EA
Pts newly referred to Rhe with EA confirmed (n=34)Pts newly referred to Rhe w/o EA confirmed (n=450)Diagnosis of EA according to a simple survey (3Q, 1 min) carried out by administrators by phone948330100
Diagnosis of EA according to a simple survey (3Q, 1 min) during a medical visit949349100
Tavares et al (2b)20Pts newly referred to Rhe with EA confirmed (n=30)Pts newly referred to Rhe w/o EA confirmed (n=113)Diagnosis of EA according to a self-administered Inflammatory Arthritis Detection Tool86876786
Study (LoE)PopulationControlsOutcomeHR (95% CI)
B. Referral of patients with EA
Feldman et al (2b)21RA diagnosed by GP with referral to specialist, within 3 months (n=533)RA diagnosed by GP with referral to specialist, beyond 3 months (n=518)Orthopaedic surgery (early vs late referral)0.60 (0.44 to 0.82)
van der Linden et al (2b)5ERA referred to specialist within 3 months (n=412)ERA with referral to specialist beyond 3 months (n=186)Drug-free remission (≥1 year) (early vs late referral)1.9 (1.2 to 3.0)
Radiographic (total SvH) progression (late vs early referral)1.3 (NR)
  • NPV and PPV are presented in percentages.

  • EA, early arthritis; LoE, level of evidence; NPV, negative predictive value; PPV, positive predictive value; Pts, patients; Q, question; Rhe, rheumatologist; Sens, sensitivity; Spec, specificity.

  • EA, early arthritis; ERA, early rheumatoid arthritis; GP, general practitioner; LoE, level of evidence; NR, not reported; RA, rheumatoid arthritis; SvH, Sharp-van der Heijde score.