Table 1

Statistical measures comparing DAS28-CRP>5.1 and DAS28-ESR>5.1 at baseline

DAS28-CRP>5.1DAS28-ESR>5.1Proportion of discordance between parametersSensitivity (%)Specificity (%)κ coefficient
COMET
ETN+MTX208/265 (78.5)244/265 (92.1)36/265 (13.6)100.036.80.48
MTX204/262 (77.9)243/263 (92.4)38/262 (14.5)100.034.50.45
PRIZE
ETN+MTX186/306 (60.8)242/306 (79.1)62/306 (20.3)98.450.80.54
Pooled
ETN+MTX394/571 (69.0)486/571 (85.1)98/571 (17.2)99.246.30.53
  • Sensitivity and specificity based on standard DAS28-CRP>5.1.

  • Values are n/N (%) unless otherwise noted.

  • DAS28-CRP, Disease Activity Score in 28 joints calculated with C reactive protein; DAS28-ESR, Disease Activity Score in 28 joints calculated with erythrocyte sedimentation rate; ETN, etanercept; MTX, methotrexate.