Statistical measures comparing DAS28-CRP>5.1 and DAS28-ESR>5.1 at baseline
| DAS28-CRP>5.1 | DAS28-ESR>5.1 | Proportion of discordance between parameters | Sensitivity (%) | Specificity (%) | κ coefficient | |
|---|---|---|---|---|---|---|
| COMET | ||||||
| ETN+MTX | 208/265 (78.5) | 244/265 (92.1) | 36/265 (13.6) | 100.0 | 36.8 | 0.48 |
| MTX | 204/262 (77.9) | 243/263 (92.4) | 38/262 (14.5) | 100.0 | 34.5 | 0.45 |
| PRIZE | ||||||
| ETN+MTX | 186/306 (60.8) | 242/306 (79.1) | 62/306 (20.3) | 98.4 | 50.8 | 0.54 |
| Pooled | ||||||
| ETN+MTX | 394/571 (69.0) | 486/571 (85.1) | 98/571 (17.2) | 99.2 | 46.3 | 0.53 |
Sensitivity and specificity based on standard DAS28-CRP>5.1.
Values are n/N (%) unless otherwise noted.
DAS28-CRP, Disease Activity Score in 28 joints calculated with C reactive protein; DAS28-ESR, Disease Activity Score in 28 joints calculated with erythrocyte sedimentation rate; ETN, etanercept; MTX, methotrexate.