Longitudinal analysis: logistic regression analysis of baseline determinants of clinical progression defined by worsened FIHOA score
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Age | 1.0 (0.97 to 1.04) | 0.38 | ||
| Sex | ||||
| Men (reference) | Ref | |||
| Menopausal women | 0.75 (0.4 to 1.44) | 0.39 | ||
| Non-menopausal women | 1.16 (0.52 to2.6) | 0.71 | ||
| BMI≥30 vs <30 kg/m2 | 1.38 (0.79 to 2.39) | 0.25 | ||
| Comorbidities | ||||
| Diabetes | 0.84 (0.35 to 2.01) | 0.69 | ||
| Hypertension | 1.1 (0.64 to1.9) | 0.72 | ||
| Dyslipidaemia | 1.16 (0.65 to 2.1) | 0.61 | ||
| Coronary heart disease | 2.39 (1.03 to 5.58) | 0.04 | 2.91 (1.02 to 8.26) | 0.045 |
| Depression | 0.44 (0.18 to 1.05) | 0.06 | ||
| Stroke | 0.91 (0.19 to 4.47) | 0.91 | ||
| Alcohol consumption | ||||
| No | ||||
| Previous use | 1.57 (0.05 to 53.27) | 0.8 | ||
| Yes | 1.01 (0.64 to 1.9) | 0.73 | ||
| Tobacco use | ||||
| No | ||||
| Previous use | 0.84 (0.45 to1.59) | 0.6 | ||
| Yes | 1.41 (0.39 to5.09) | 0.59 | ||
| Clinical variables | ||||
| FIHOA | 0.77 (0.72 to 0.83) | <0.001 | 0.956 (0.88 to 1.038) | 0.28 |
| Radiographic variables | ||||
| KL hand score | 0.99 (0.97 to 1.01) | 0.27 | ||
Statistically significant results are in bold.
FIHOA, Functional Index for Hand Osteoarthritis; KL, Kellgren-Lawrence.