Table 5

Multivariate logistic regression analysis of gout susceptibility with rare and common variants of ABCG2

VariablesβOR (95% CI)p Value
Rare variant0.992.7 (1.4 to 5.2)3.0×10−3
Q126X1.213.4 (2.0 to 5.6)3.1×10−6
Q141K0.852.3 (1.9 to 2.9)2.7×10−16
  • Each variant was adjusted by the other two variants in this analysis.

  • Since the P268S variant of ABCG2 did not decrease urate transport activity, it was excluded from this analysis.

  • The A149P variant of ABCG2 was also excluded from this analysis due to its scores of SIFT and PolyPhen-2 as well as a previous report of functional analysis.18

  • ABCG2, ATP-binding cassette transporter subfamily G member 2; PolyPhen-2, Polymorphism Phenotyping v2; SIFT, Sorting Intolerant from Tolerant.