Table 1

Timeline of pneumococcal vaccine development

1911Starting pneumococcal vaccine research development
1915–1945Description of chemical structure of pathogen, virulence factors, antigenicity and serotypes. In 1940 more than 80 serotypes were known.
1977Introduction of pneumococcal polysaccharide vaccine with 14 serotypes (PPV-14) in USA
1983Introduction of pneumococcal polysaccharide vaccine with 23 serotypes (PPV-23)
2000First development of pneumococcal conjugate vaccine with seven serotypes (PCV-7)
2009Introduction of pneumococcal conjugate vaccine with 10 serotypes (PCV-10) received by European Commission authorisation
2010Introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) for children (6 weeks to 71 months)
December 2011First application of PCV-13 in adults ≥50 years
June 2012ACIP recommendation of PCV-13 for adults aged ≥19 years with immunocompromising conditions
January 2013PCV-13 for teenagers (6–17 years)
July 2013EMA recommendation of PCV-13 for all ages
  • ACIP, Advisory Committee on Immunization Practices; EMA, European Medicines Agency.