Baseline demographics and disease characteristics
| Characteristics | CONCERTO (n=395) | MUSICA (n=309) |
| Age, years | 51.9±13.5 | 54.8±12.1 |
| Female, n (%) | 300 (75.9) | 231 (74.8) |
| Rheumatoid factor-positive, n (%) | 330 (83.5) | 210 (68.9) |
| Duration of RA, years | 0.32±0.5 | 5.3±7.6 |
| DAS28(CRP) | 6.0±1.0* | 5.8±0.9† |
| TJC (0–68 joints) | 27.1±14.6 | 31.2±17.0 |
| SJC (0–66 joints) | 18.0±12.4 | 18.3±10.9 |
| HAQ-DI (range 0–3) | 1.6±0.7 | 1.5±0.6 |
| Prior biologic DMARD, n (%) | NA | 17 (5.5) |
| Prior MTX, mg/week | NA | 17.3±2.3 |
Data are mean±SD unless otherwise indicated. In CONCERTO, patients were naïve to MTX and biologic DMARDs. In MUSICA patients had an inadequate response to MTX.
*n=386.
†n=302.
DAS28(CRP), 28 Joint Disease Activity Score based on C reactive protein; DMARD, disease-modifying antirheumatic drug; HAQ-DI, Health Assessment Questionnaire-Disability Index; MTX, methotrexate; RA, rheumatoid arthritis; SJC, swollen joint count; TJC, tender joint count; NA, not applicable.