Health-related quality of life scores for SF-12v2 dimensions and PHQ-9 depression status stratified by SS classification and symptoms among 2527 SICCA* participants
| Symptomatic participants (total=2401) | Asymptomatic participants (total=126) | |||||
| SS (N=1051) | Non-SS (N=1350) | p Value† | SS (N=66) | Non-SS (N=60) | p Value† | |
| SF-12v2, mean±SD | ||||||
| Physical function | 46.0±10.7 | 42.6±11.5 | <0.001 | 52.2±8.4 | 52.6±7.2 | 0.76 |
| Physical role functioning | 44.2±10.3 | 40.1±10.4 | <0.001 | 51.3±9.5 | 50.4±8.2 | 0.54 |
| Bodily pain | 44.5±11.3 | 39.9±11.6 | <0.001 | 50.6±10.3 | 49.6±9.6 | 0.57 |
| General health | 41.8±10.7 | 40.5±11.2 | 0.004 | 44.5±10.6 | 46.8±10.4 | 0.22 |
| Vitality | 47.0±11.2 | 43.6±10.8 | <0.001 | 53.2±11.7 | 53.2±11.9 | 0.97 |
| Social functioning | 46.0±10.4 | 42.7±11.2 | <0.001 | 49.9±10.3 | 49.8±8.8 | 0.95 |
| Emotional role functioning | 44.6±11.3 | 42.0±11.8 | <0.001 | 50.5±10.0 | 50.2±8.5 | 0.85 |
| Mental health | 46.5±10.6 | 44.2±10.5 | <0.001 | 52.7±9.0 | 50.3±10.6 | 0.16 |
| Physical component measure (PCS) | 44.2±10.3 | 40.5±11.4 | <0.001 | 49.6±8.8 | 50.2±7.6 | 0.66 |
| Mental component measure (MCS) | 46.4±10.3 | 44.3±10.8 | <0.001 | 51.7±9.2 | 50.3±10.6 | 0.43 |
| PHQ-9, n (%) | <0.001 | 0.20 | ||||
| No depression | 439 (42) | 388 (29) | 55 (83) | 41 (68) | ||
| Mild | 289 (27) | 396 (29) | 7 (11) | 11 (18) | ||
| Moderate | 159 (15) | 276 (20) | 2 (3) | 6 (10) | ||
| Moderately severe | 76 (7) | 163 (12) | 0 (0) | 1 (2) | ||
| Severe | 39 (4) | 97 (7) | 2 (3) | 1 (2) | ||
*Participants from the Sjögren’s International Collaborative Clinical Alliance registry.
†Kruskal-Wallis test and χ2 test used to determine the relationship between SS and non-SS participants.
MCS, mental component summary; PCS, physical component summary; PHQ-9, 9-Item Patient Health Questionnaire; SF-12v2, Short Form 12, version 2; SS, Sjögren’s syndrome.