Sjögren’s syndrome (SS)-related characteristics stratified by SS classification and symptoms among 2527 SICCA* participants
| Symptomatic participants (total=2401) | Asymptomatic participants (total=126) | |||||
| SS (N=1051) | Non-SS (N=1350) | p Value† | SS (N=66) | Non-SS (N=60) | p Value† | |
| Symptoms, median years (Q1–Q3) | ||||||
| Reported duration of dry mouth symptoms | 4.0 (1.7–9.7) | 2.9 (1.0–7.3) | 0.002 | NA | NA | NA |
| Reported duration of dry eye symptoms | 4.3 (1.8–9.8) | 3.9 (1.4–9.1) | 0.22 | NA | NA | NA |
| SS-related findings, n (%) | ||||||
| Labial salivary gland with FLS and FS ≥1 foci/4 mm | 852 (82) | 49 (4) | <0.001 | 44 (67) | 3 (5) | <0.001 |
| Anti-SSA/Ro-positive | 799 (76) | 44 (3) | <0.001 | 60 (91) | 8 (13) | <0.001 |
| OSS ≥5 in at least one eye | 838 (80) | 468 (35) | <0.001 | 49 (74) | 16 (27) | <0.001 |
| Schirmer’s test ≤5 mm/5 min in at least one eye | 614 (58) | 389 (29) | <0.001 | 20 (30) | 10 (17) | 0.08 |
| UWS flow rate ≤0.1 mL/min | 748 (71) | 582 (43) | <0.001 | 17 (26) | 6 (10) | 0.02 |
*Participants from the Sjögren’s International Collaborative Clinical Alliance registry.
†Kruskal-Wallis test and χ2 test used to determine the relationship between SS and non-SS.
FLS, focal lymphocytic sialadenitis; FS, focus score; OSS, ocular staining score; NA, not applicable; UWS, unstimulated whole saliva.