Table 2

Univariate analysis of good/moderate EULAR response at W24 by genotype

Candidate geneCandidate variantsGenotype*Good/moderate respondersNon-respondersp Value
IRF5rs20046400 (T/T)1710
1 (T/G)5680.030‡
2 (G/G)124
IRF7rs11316650 (T/T)4515
1 (T/C)3560.180
2 (C/C)111
SPP1rs114390600 (–/–)4813
1 (–/G)307
2 (GG)1310.410
rs91380 (A/A)456
1 (C/A)33120.085
2 (C/C)114
STAT4rs75748650 (G/G)4112
1 (G/T)426
2 (T/T)740.284
TNFSF13Brs95148280 (C/C)363
1 (C/T)4311
2 (T/T)1380.035‡
TYK2rs127203560 (T/T)7320
1 (T/G)1320.490
2 (G/G)30
rs23042560 (C/C)458
1 (C/A)35110.515
2 (A/A)81
rs2805190 (A/A)276
1 (A/G)3712
2 (G/G)2840.376
  • Grey indicates the selected model (dominant or recessive).

  • *0 denotes patients homozygous for the major allele; 1, heterozygous; 2, homozygous for the rare allele.

  • †p<0.20.

  • ‡p<0.05.

  • EULAR, European League Against Rheumatism.