Activated platelets in patients with systemic lupus erythematosus (SLE) with endothelial activation
| Endothelial activation | Platelet/C4d high | Platelet/C1q high | ||||
| OR | 95% CI | p Value | OR | 95% CI | p Value | |
| sVCAM-1 high* | 4.57 | 2.14 to 9.79 | <0.01 | 4.10 | 1.09 to 15.38 | 0.04 |
| sVCAM-1 high† | 4.17 | 1.90 to 9.15 | <0.01 | 4.15 | 1.07 to 16.18 | 0.04 |
| EMP high* | 3.64 | 1.16 to 11.38 | 0.03 | 2.16 | 0.51 to 9.16 | 0.30 |
| EMP high† | 3.11 | 0.97 to 9.98 | 0.056 | 2.05 | 0.47 to 8.91 | 0.34 |
OR for markers of platelet activation; platelet-C4d and platelet C1q deposition was calculated in patients with SLE with and without high sVCAM-1 and high EMP levels. Endothelial activation and platelet activation values are dichotomous.
*Adjusted for age, gender, p-LDL concentration.
†Adjusted for age, gender, p-LDL and IFN activity.
EMP, endothelial microparticles; IFN, interferon; LDL, low density lipoprotein; platelet-C4d/platelet-C1q, platelet-C4d/C1q deposition; sVCAM-1, soluble vascular cell adhesion molecule-1.