Treatment at 3, 5 and 8 years from baseline (n (%))
| 3 years n=625 | 5 years n=625 | 8 years n=454 | |
| Still on initial TNFi | 385 (61) | 292 (47) | 150 (33) |
| Started a second TNFi within period | 168 (27) | 229 (37) | 264 (42) |
| On second TNFi at time point | 110 (18) | 124 (20) | 72 (16) |
| Started a third TNFi within period | 39 (6) | 62 (10) | 96 (15) |
| On third or subsequent TNFi at time point | 35 (6) | 44 (7) | 53 (12) |
| Started non-TNFi biologic within period | 4 (0.6) | 9 (1) | 19 (3) |
| On other non-TNFi biologic treatment at time point | 2 (0.3) | 3 (0.5) | 8 (2) |
| Not on biologic treatment | 68 (11) | 77 (12) | 45 (10) |
| Died | 10 (2) | 23 (4) | 34 (8) |
| Lost to follow-up | 15 (2) | 62 (10) | 92 (20) |