Key studies and observations used in the design of SEAM-PsA
| Study (Reference) | Observation |
| Methotrexate in Psoriatic Arthritis (MIPA)3 | Methotrexate monotherapy at 15 mg/week did not result in statistically significant improvements compared with placebo |
| Etanercept PsA pivotal phase 3 study6 11 | Similar efficacy was demonstrated between etanercept monotherapy and combination therapy with etanercept plus methotrexate |
| Norwegian Disease-modifying Antirheumatic Drugs Longitudinal Observational Study (NOR-DMARD)7 Corrona registry8 | Combination therapies that are efficacious in patients with RA do not provide similar efficacy in patients with PsA |
PsA, psoriatic arthritis; RA, rheumatoid arthritis; SEAM-PsA, Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis.