Plasma and urine pharmacokinetics of allopurinol and oxypurinol following once-daily oral administration of varying verinurad doses in combination with allopurinol 300 mg once daily (geometric means and geometric least-squares mean ratios, 95% CIs)
| Verinurad (mg) | Allopurinol | Oxypurinol | ||||||||||
| Geometric mean (95% CI) | GMR (%) (90% CI) | Geometric mean (95% CI) | GMR (%) (90% CI) | |||||||||
| Cmax (µg/mL) | AUClast (µg·hour/mL) | CLR0–24 (mL/min) | Cmax | AUClast | CLR0–24 | Cmax (µg/mL) | AUClast (µg·hour/mL) | CLR0–24 (mL/min) | Cmax | AUClast | CLR0-24 | |
| 0 | 1.18 (1.03 to 1.36) | 3.70 (3.28 to 4.18) | 91.3 (82.1 to 101) | – | – | – | 12.2 (11.1 to 13.4) | 243 (218 to 271) | 14.5 (13.2 to 15.9) | – | – | – |
| 2.5 | 1.16 (0.911 to 1.47) | 3.59 (2.87 to 4.49) | 82.0 (67.8 to 99.2) | 103 (90.7 to 117) | 100 (94.3 to 107) | 92.1 (86.2 to 98.3) | 10.2 (8.91 to 11.8) | 199 (171 to 233) | 18.4 (16.2 to 21.0) | 81.0 (75.9 to 86.5) | 79.2 (74.2 to 84.5) | 132 (122 to 143) |
| 5 | 1.16 (0.937 to 1.43) | 3.76 (3.20 to 4.41) | 78.6 (70.1 to 88.2) | 92.6 (78.1 to 110) | 98.0 (90.4 to 106) | 86.9 (81.6 to 92.5) | 9.39 (8.46 to 10.4) | 181 (161 to 202) | 21.7 (19.2 to 24.6) | 79.8 (75.2 to 84.7) | 76.9(72.0 to 82.2) | 145 (135 to 156) |
| 7.5 | 1.14 (0.905 to 1.44) | 3.71 (3.04 to 4.54) | 76.6 (63.2–92.8) | 102 (85.7 to 120) | 104 (94.5 to 114) | 85.4 (79.3 to 92.1) | 9.8 (8.54 to 11.2) | 185 (158 to 216) | 21.8 (18.8 to 25.3) | 77.6 (69.8 to 86.2) | 73.4(66.2 to 81.3) | 155 (142 to 168) |
| 10 | 1.11 (0.928 to 1.33) | 3.53 (2.99 to 4.16) | 86.4 (75.2 to 99.2) | 88.9 (78.4 to 101) | 92.0 (86.7 to 97.7) | 96.2 (91.2 to 101) | 8.76 (7.96 to 9.64) | 164 (147 to 182) | 25.9 (22.7 to 29.6) | 74.4 (70.5 to 78.6) | 69.6 (65.4 to 74.0) | 175 (160 to 190) |
| 15 | 1.12 (0.877 to 1.44) | 3.53 (2.84 to 4.39) | 73.5 (61.2 to 88.3) | 100 (87.7 to 114) | 98.9 (91.0 to 107) | 85.2 (78.7 to 92.3) | 8.54 (7.62 to 9.58) | 153 (133 to 176) | 25.7 (22.2 to 29.7) | 67.6 (61.1 to 74.9) | 60.8(55.3 to 66.9) | 185 (169 to 202) |
| 20 | 1.26 (1.02 to 1.56) | 3.74 (3.21 to 4.34) | 82.2 (75.7 to 89.3) | 101 (85.5 to 119) | 97.5 (92.8 to 102) | 90.7 (85.7 to 96.0) | 8.38 (7.58 to 9.28) | 151 (135 to 168) | 30.0 (26.8 to 33.5) | 71.3 (66.4 to 76.5) | 64.2(59.6 to 69.1) | 201 (183 to 221) |
AUClast, area under the plasma concentration–time curve from time zero to the last measurable time point; CLR0–24, renal clearance from time zero to 24 hours; Cmax, maximum observed concentration; GMR, geometric least squares mean ratio.