Table 3

Plasma and urine pharmacokinetics of allopurinol and oxypurinol following once-daily oral administration of varying verinurad doses in combination with allopurinol 300 mg once daily (geometric means and geometric least-squares mean ratios, 95% CIs)

Verinurad (mg)AllopurinolOxypurinol
Geometric mean (95% CI)GMR (%) (90% CI)Geometric mean (95% CI)GMR (%) (90% CI)
Cmax (µg/mL)AUClast (µg·hour/mL)CLR0–24 (mL/min)CmaxAUClastCLR0–24Cmax (µg/mL)AUClast (µg·hour/mL)CLR0–24 (mL/min)CmaxAUClastCLR0-24
01.18
(1.03 to 1.36)
3.70
(3.28 to 4.18)
91.3
(82.1 to 101)
12.2
(11.1 to 13.4)
243
(218 to 271)
14.5
(13.2 to 15.9)
2.51.16
(0.911 to 1.47)
3.59
(2.87 to 4.49)
82.0
(67.8 to 99.2)
103
(90.7 to 117)
100
(94.3 to 107)
92.1
(86.2 to 98.3)
10.2
(8.91 to 11.8)
199
(171 to 233)
18.4
(16.2 to 21.0)
81.0 (75.9 to 86.5)79.2
(74.2 to 84.5)
132
(122 to 143)
51.16
(0.937 to 1.43)
3.76
(3.20 to 4.41)
78.6
(70.1 to 88.2)
92.6
(78.1 to 110)
98.0
(90.4 to 106)
86.9
(81.6 to 92.5)
9.39
(8.46 to 10.4)
181
(161 to 202)
21.7
(19.2 to 24.6)
79.8
(75.2 to 84.7)
76.9(72.0 to 82.2)145
(135 to 156)
7.51.14
(0.905 to 1.44)
3.71
(3.04 to 4.54)
76.6
(63.2–92.8)
102
(85.7 to 120)
104
(94.5 to 114)
85.4
(79.3 to 92.1)
9.8
(8.54 to 11.2)
185
(158 to 216)
21.8
(18.8 to 25.3)
77.6
(69.8 to 86.2)
73.4(66.2 to 81.3)155
(142 to 168)
101.11
(0.928 to 1.33)
3.53
(2.99 to 4.16)
86.4
(75.2 to 99.2)
88.9
(78.4 to 101)
92.0
(86.7 to 97.7)
96.2
(91.2 to 101)
8.76
(7.96 to 9.64)
164
(147 to 182)
25.9
(22.7 to 29.6)
74.4
(70.5 to 78.6)
69.6 (65.4 to 74.0)175
(160 to 190)
151.12
(0.877 to 1.44)
3.53
(2.84 to 4.39)
73.5
(61.2 to 88.3)
100
(87.7 to 114)
98.9
(91.0 to 107)
85.2
(78.7 to 92.3)
8.54
(7.62 to 9.58)
153
(133 to 176)
25.7
(22.2 to 29.7)
67.6
(61.1 to 74.9)
60.8(55.3 to 66.9)185
(169 to 202)
201.26
(1.02 to 1.56)
3.74
(3.21 to 4.34)
82.2
(75.7 to 89.3)
101
(85.5 to 119)
97.5
(92.8 to 102)
90.7
(85.7 to 96.0)
8.38
(7.58 to 9.28)
151
(135 to 168)
30.0
(26.8 to 33.5)
71.3
(66.4 to 76.5)
64.2(59.6 to 69.1)201
(183 to 221)
  • AUClast, area under the plasma concentration–time curve from time zero to the last measurable time point; CLR0–24, renal clearance from time zero to 24 hours; Cmax, maximum observed concentration; GMR, geometric least squares mean ratio.