Structural joint damage in patients randomised to CZP treatment at Week 0
| (A) Change in mTSS from baseline to Week 216 | |
| Week 0 CZP dose combined (n=273) | |
| mTSS at baseline | |
| Observed case (n=269) | |
| Mean (SD) | 16.03 (34.67) |
| Median | 4.50 |
| (Min, max) | (0, 342.5) |
| MMRM estimates, least squares (LS) mean (SE), 95% CI | |
| mTSS at baseline | 15.96 (2.24), 11.55 to 20.36 |
| CFB at Week 96 | 0.28 (0.12), 0.04 to 0.51 |
| CFB at Week 168 | 0.62 (0.19), 0.25 to 0.99 |
| CFB at Week 216 | 0.72 (0.20), 0.33 to 1.11 |