Demographic characteristics and serum urate levels (safety population)
| Cohort 1 (n=14) | Cohort 2 (n=12) | Cohort 3 (n=12) | Cohort 4 (n=14) | Cohort 5 (n=12) | Overall (n=64) | |
| Age, years, mean (SD) | 45 (8.9) | 50 (8.2) | 50 (8.5) | 48 (11.5) | 49 (10.9) | 48 (9.6) |
| Body weight, kg, mean (SD) | 92.2 (16.11) | 93.8 (15.37) | 101.5 (18.36) | 104.7 (16.54) | 102.5 (20.38) | 98.9 (17.58) |
| BMI, kg/m2, mean (SD) | 30.2 (4.24) | 30.8 (3.43) | 33.8 (4.37) | 33.8 (3.35) | 34.2 (4.32) | 32.5 (4.20) |
| Race (n, %) | ||||||
| Asian (other) | 6 (42.9) | 3 (25.0) | 1 (8.3) | 2 (14.3) | 2 (16.7) | 14 (21.9) |
| Black or African-American | 1 (7.1) | 2 (16.7) | 1 (8.3) | 2 (14.3) | 1 (8.3) | 7 (10.9) |
| White | 7 (50.0) | 7 (58.3) | 10 (83.3) | 10 (71.4) | 9 (75.0) | 43 (67.2) |
| Ethnicity (n, %) | ||||||
| Hispanic or Latino | 4 (28.6) | 2 (16.7) | 9 (75.0) | 6 (42.9) | 5 (41.7) | 26 (40.6) |
| Not Hispanic or Latino | 10 (71.4) | 10 (83.3) | 3 (25.0) | 8 (57.1) | 7 (58.3) | 38 (59.4) |
| Serum urate, mg/dL, mean (SD) | 8.6 (0.74) | 9.5 (2.01) | 9.6 (1.17) | 9.3 (1.57) | 9.6 (1.39) | 9.3 (1.45) |
BMI, body mass index.