Unadjusted and adjusted HRs for flare
| Unadjusted HRs | ||
| HR (95% CI) | P values | |
| Demographic variables | ||
| Age, years | 1.02 (0.99 to 1.04) | 0.24 |
| Gender (male) | 0.87 (0.42 to 1.82) | 0.72 |
| Disease duration, years | 1.01 (0.97 to 1.04) | 0.78 |
| BMI | 1.03 (0.97 to 1.09) | 0.38 |
| Treatment arm | ||
| Taper 1/3rd | 1.28 (0.55 to 2.98) | 0.57 |
| Taper 2/3rd | 2.51 (1.06 to 5.96) | 0.04 |
| Clinical variables | ||
| DAS28 | ||
| Unadjusted | 1.86 (1.19 to 2.92) | 0.01 |
| Adjusted (age, gender, trial arm) | 1.96 (1.18 to 3.24) | 0.01 |
| Mental health variables | ||
| HAQ-DI | ||
| Unadjusted | 1.45 (0.99 to 2.13) | 0.06 |
| Adjusted (age, gender, trial arm) | 1.43 (0.91 to 2.29) | 0.13 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 1.16 (0.72 to 1.87) | 0.53 |
| EQ-5D | ||
| Unadjusted | 0.28 (0.07 to 1.24) | 0.09 |
| Adjusted (age, gender, trial arm) | 0.29 (0.06 to 1.38) | 0.12 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 0.51 (0.10 to 2.58) | 0.42 |
| EQ-5D depression anxiety | ||
| Unadjusted | 1.42 (0.70 to 2.87) | 0.33 |
| Adjusted (age, gender, trial arm) | 1.37 (0.64 to 2.96) | 0.41 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 1.51 (0.70 to 3.28) | 0.29 |
| FACIT-F (per 10 unit) | ||
| Unadjusted | 0.68 (0.47 to 0.99) | 0.04 |
| Adjusted (age, gender, trial arm) | 0.78 (0.48 to 1.14) | 0.18 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 0.77 (0.50 to 1.16) | 0.20 |
| SF-36 PCS (per 10 unit) | ||
| Unadjusted | 0.74 (0.55 to 0.99) | 0.05 |
| Adjusted (age, gender, trial arm) | 0.72 (0.52 to 1.00) | 0.05 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 0.86 (0.60 to 1.23) | 0.41 |
| SF-36 MCS (per 10 unit) | ||
| Unadjusted | 0.90 (0.62 to 1.31) | 0.58 |
| Adjusted (age, gender, trial arm) | 0.93 (0.60 to 1.44) | 0.74 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 0.83 (0.54 to 1.28) | 0.41 |
| SF-36 MH (per 10 unit) | ||
| Unadjusted | 0.81 (0.67 to 0.96) | 0.01 |
| Adjusted (age, gender, trial arm) | 0.80 (0.65 to 0.98) | 0.03 |
| Adjusted (age, gender, trial arm, BMI, DAS28) | 0.75 (0.60 to 0.93) | 0.01 |
BMI, body mass index; DAS28, 28-joint count Disease Activity Score; EQ-5D, EuroQol 5-dimension scale; FACIT, Functional Assessment of Chronic Illness Therapy fatigue scale; HAQ-DI, Health Assessment Questionnaire Disability Index; SF36 MCS, mental component summary; SF36 MH, Mental Health subscale; SF36 PCS, physical component summary.