Table 3

HRs for the risk of foot and ankle tendinopathy and enthesopathy

ModelHR (95% CI)P values
Unadjusted model
 Psoriasis1.25 (1.20 to 1.30)<0.0001
Multivariable adjusted model
 Psoriasis1.25 (1.17 to 1.33)<0.0001
 Age1.44 (1.42 to 1.47)<0.0001
 Obesity status2.08 (2.04 to 2.12)<0.0001
 Smoking status0.92 (0.91 to 0.93)<0.0001
 Alcohol use1.14 (1.12 to 1.16)<0.0001
 Charlson Comorbidity Index1.19 (1.16 to 1.21)<0.0001
 Townsend Deprivation Index0.95 (0.95 to 0.96)<0.0001
 Systemic psoriasis therapy0.61 (0.56 to 0.67)<0.0001
 Systemic steroid use0.88 (0.86 to 0.90)<0.0001
 Fluoroquinolone use0.74 (0.72 to 0.76)<0.0001
  • Cox proportional-hazards models were used to estimate the Hrs of developing foot and ankle tendinopathy or enthesopathy based on whether patients had psoriasis or not (ie, psoriasis vs general population). As can be seen from these models, psoriasis significantly increases the risk of developing foot and ankle tendinopathy or enthesopathy when using unadjusted models as well as models accounting for numerous covariates.