Table 1

Characteristics of patients with RA who are NRAS members, or who responded to a survey on HU and those identified from CPRD

CPRD (N=20 594)NRAS (N=2044)Difference in proportion compared with CPRD (95% CI)P valuesHU(N=615)Difference in proportion compared with CPRD (95% CI)P values
n (%)n (%)n (%)
Age (years)
 18–34 499 (2.4) 37 (1.8)0.6 (−0.002 to 1.2)0.08 26 (4.2)−1.8 (−3.4 to −0.02)0.005
 35–44 1249 (6.1)129 (6.3)−0.2 (−1.3 to 0.9)0.6679 (12.9)−6.8 (−9.4 to −4.1)<0.001
 45–54 2936 (14.3)311 (15.2)−1 (−3 to 0.7)0.24195 (31.7)−17.5 (−21.2 to −13.7)<0.001
 55–64 4484 (21.8)568 (27.8)−6 (−8 to −4)<0.001218 (35.5)−13.7 (−17.5 to −9.9)<0.001
 65–74 5643 (27.4)709 (34.7)−7 (−9 to −5)<0.00181 (13.2)14.2 (11.5 to 17.0)<0.001
 75 and over5783 (28)290 (14.2)13.9 (12.3 to 15.5)<0.00116 (2.6)25.4 (24.1 to 26.9)<0.001
Gender
 Female14 440 (70.1)1728 (84.5)−0.18 (−0.21 to −0.16)<0.001544 (88.5)−18.3 (−20.9 to −15.7)<0.001
Year of RA diagnosis
 <199034 (0.2)274 (14.5)−14.3 (−15.9 to −12.7)<0.00139 (6.3)−6.2 (−8.1 to −4.2)<0.001
 1990–1994869 (4.2)122 (6.5)−2.2 (−3.4 to −1.1)<0.00122 (3.6)0.6 (−0.9 to 2.1)0.43
 1995–19991756 (8.5)178 (9.4)−0.9 (−2.3 to 0.5)0.1932 (5.2)3.3 (1.5 to 5.1)0.004
 2000–20044336 (21.1)304 (16.1)5.0 (3.2 to 6.7)<0.00146 (7.5)13.5 (11.4 to 15.7)<0.001
 2005–20095962 (29)540 (28.6)0.4 (−1.7 to 2.5)0.7295 (15.5)13.5 (10.6 to 16.4)<0.001
 2010–20167637 (37.1)473 (25)12.1 (10 to 14.1)<0.001381 (62)−24.9 (−28.8 to −21.0)<0.001
 Missing01530
Employment status
 Full-time employed543 (24.1)387 (23.6)
 Part-time employed418 (18.5)288 (17.5)
 Unemployed304 (13.5)280 (17)
 Retired698 (30.9)577 (35.1)
 Retired due to arthritis151 (6.7)83 (5.1)
 Not working due to ill health142 (6.3)28 (1.7)
 MissingNA4010
Ethnicity
 White8931 (93.9)1572 (98.4)−4.5 (−5.3 to −3.7)<0.001578 (94.6)−0.73 (−2.6 to 1.1)0.47
 Mixed44 (0.5)5 (0.3)0.1 (−0.2 to 0.5)0.408 (1.3)−0.8 (−1.8 to 0.06)0.005
 Asian315 (3.3)12 (0.8)2.6 (2.0 to 3.1)<0.00111 (1.8)1.5 (0.3 to 2.6)0.04
 Black147 (1.6)5 (0.3)1.2 (0.9 to 1.6)<0.00113 (2.1)−0.58 (−1.8 to 0.6)0.26
 Other77 (0.8)4 (0.3)0.6 (0.3 to 0.9)0.021 (0.2)0.6 (0.3 to 1.0)0.08
 Missing11 0804462
Townsend Deprivation Index
 1 (least deprived)2807 (23.1)103 (18.3)4.9 (1.6 to 8.1)0.007
 22949 (24.3)112 (19.9)4.4 (1 to 7.8)0.016
 32543 (20.9)107 (19)2.0 (−1.3 to 5.3)0.26
 42329 (19.2)119 (21.1)−1.9 (−5.4 to 1.5)0.26
 5 (most deprived)1514 (12.5)123 (21.8)−9.3 (−12.8 to -5.9)<0.001
 Missing8452NA49
Ever taken methotrexate
 Yes14 553 (70.7)1783 (87.2)−16.6 (−18.1 to −15.0)<0.001511 (84.9)−14.2 (−17.1 to −11.3)<0.001
 Missing or unknown0013
Ever taken sulfasalazine
 Yes9742 (47.3)1064 (52.1)−4.7 (−7 to −2.5)<0.001339 (56.9)−9.6 (−13.6 to −5.5)<0.001
 Missing or unknown0019
Ever taken hydroxychloroquine
 Yes8255 (40.1)883 (43.2)−3.1 (−5.4 to −0.9)0.006359 (60.1)−20 (−24 to −16)<0.001
 Missing or unknown0018
Ever taken leflunomide
 Yes2576 (12.5)378 (18.5)−6 (−7.7 to −4.2)<0.001113 (19)−6.5 (−9.7 to −3.3)<0.001
 Missing or unknown0021
Ever taken DMARDs*
 Yes18 683 (90.7)1956 (95.7)−5 (−6 to −4)<0.001537 (93.4)−2.7 (−4.7 to −0.6)0.029
 Missing or unknown00106
Ever taken glucocorticoids
 Yes11 889 (57.7)351 (17.2)40.6 (38.8 to 42.3)<0.001368 (61.7)−4 (−8 to −0.05)0.05
 Missing or unknown0019
Ever taken biologics
 Yes897 (43.9)196 (32.9)
 Missing or unknown20 594020
  • *Ever taken DMARDs is based on the ever taken methotrexate, ever taken sulfasalazine, ever taken hydroxychloroquine and ever taken leflunomide data.

  • CPRD, Clinical PracticeResearch Datalink; DMARD, disease-modifyingantirheumatic drug; HU, HealthUnlocked.com; NA, not available; NRAS, National RheumatoidArthritis Society; RA, rheumatoid arthritis.