HLA-F allelic and genotypic frequencies in patients with HLA-B27 AS and HLA-B27 controls
| HLA-B27 Portuguese patients with AS | HLA-B27 Portuguese unaffected controls | ||||||
| Alleles | FAs | Fc | P values | pCA | Bonferroni | OR (95% CI) | |
| F*01:01:01 | 0.54 | 0.52 | 0.59 | 1.08 (0.83 to 1.41) | |||
| F*01:01:02 | 0.14 | 0.21 | 0.005 | 0.01 | 0.60 (0.42 to 0.86) | ||
| F*01:01:03 | 0.13 | 0.13 | 0.92 | 1.02 (0.69 to 1.52) | |||
| F*01:03:01 | 0.18 | 0.13 | 0.04 | 0.08 | 1.48 (1.03 to 2.13) | ||
| F*01:04 | 0.01 | 0.01 | 1.00 | 0.85 (0.19 to 3.82) | |||
| Genotypes | FAs | Fc | P values | Bonferroni | OR (95% CI) | ||
| F*01:01:01/F*01:01:01 | 0.30 | 0.30 | 1.00 | 1.01 (0.67 to 1.51) | |||
| F*01:01:01/F*01:01:02 | 0.14 | 0.20 | 0.08 | 0.63 (0.38 to 1.05) | |||
| F*01:01:01/F*01:01:03 | 0.15 | 0.14 | 0.79 | 1.12 (0.66 to 1.90) | |||
| F*01:01:01/F*01:03:01 | 0.19 | 0.11 | 0.01 | 0.04 | 2.01 (1.17 to 3.44) | ||
| F*01:01:01/F*01:04 | 0.005 | 0.004 | 1.00 | 1.14 (0.07 to 18.25) | |||
| F*01:01:02/F*01:01:02 | 0.05 | 0.04 | 0.65 | 1.27 (0.51 to 3.20) | |||
| F*01:01:02/F*01:01:03 | 0.01 | 0.06 | 0.02 | 0.08 | 0.25 (0.07 to 0.89) | ||
| F*01:01:02/F*01:03:01 | 0.03 | 0.08 | 0.01 | 0.04 | 0.32 (0.13 to 0.82) | ||
| F*01:01:02/F*01:04 | 0.00 | 0.004 | 1.00 | 0 | |||
| F*01:01:03/F*01:01:03 | 0.05 | 0.01 | 0.03 | 0.11 | 4.33 (1.19 to 15.75) | ||
| F*01:01:03/F*01:03:01 | 0.02 | 0.03 | 0.59 | 0.70 (0.23 to 2.18) | |||
| F*01:01:03/F*01:04 | 0.0000 | 0.004 | 1.00 | 0 | |||
| F*01:03:01/F*01:03:01 | 0.04 | 0.02 | 0.24 | 2.32 (0.69 to 7.81) | |||
| F*01:03:01/F*01:04 | 0.01 | 0.004 | 0.60 | 2.28 (0.21 to 25.33) | |||
| SNP | Alleles | AS MAF | C MAF | P values | pCA | Bonferroni | OR (95% CI) |
| rs2075682 | T/A | 0.12 | 0.21 | 0.0004 | 0.0008 | 0.53 (0.37 to 0.75) | |
| rs17875380 | A/C | 0.007 | 0.01 | 0.55 | 0.65 (0.15 to 2.72) | ||
| rs1736924 | C/T | 0.18 | 0.13 | 0.03 | 0.059 | 1.48 (1.03 to 2.13) | |
| rs1736922 | T/C | 0.15 | 0.14 | 0.79 | 1.05 (0.73 to 1.52 |
| SNP | Alleles | AS MAF | C MAF | P values | pCA | OR (95% CI) | |
| rs2075682 | T/A | 0.11 | 0.14 | 0.10 | 0.11 | 0.75 (0.54 to 1.06) | |
| rs17875380 | A/C | 0.007 | 0.008 | 1.00 | 0.78 | 0.83 (0.23 to 3.04) | |
| rs1736924 | C/T | 0.17 | 0.17 | 1.00 | 0.99 | 1.00 (0.75 to 1.34) | |
| rs1736922 | T/C | 0.18 | 0.21 | 0.27 | 0.25 | 0.85 (0.65 to 1.13) |
AS, ankylosing spondylitis; AAS MAF, minor allele frequency in AS patient group; Bonferroni, Bonferroni corrected p value; C MAF, minor allele frequency in control group; FAs, frequency in patient group; Fc, frequency in control group; P value, Fisher’s exact test; pCA, Cochrane-Armitage test of trend; SNP, single nucleotide polymorphism.