Patient-reported clinical, functional and health-related quality of life outcomes for latent profiles
| All participants | Low PtGA/low MDGA (n=222) | Moderate PtGA/moderate MDGA (n=115) | High PtGA/high MDGA (n=91) | High PtGA/low MDGA (n=144) | Low PtGA/high MDGA (n=46) | P values |
| Pain VAS | 2.1±0.1a | 5.0±0.2b | 6.9±0.2c | 6.4±0.2d | 3.8±0.3e | <0.001 |
| Fatigue VAS | 2.0±0.2a | 4.5±0.2b | 6.0±0.3c | 5.2±0.2d | 3.0±0.4e | <0.001 |
| PHQ-9 | 3.5±0.4a | 6.5±0.5b | 10.6±0.6c | 8.9±0.5d | 4.7±0.8ab | <0.001 |
| HAQ-DI | 0.8±0.1a | 1.4±0.1b | 1.8±0.1c | 1.5±0.1b | 1.3 ±0.1b | <0.001 |
| Activity impairment | 27.6±1.7a | 56.8±2.3b | 72.8±2.6c | 62.4±2.1b | 43.2±3.7d | <0.001 |
| SF-36 PCS | 43.7±0.6a | 32.4±0.8b | 26.9±0.9c | 30.9±0.7b | 36.4±1.2d | <0.001 |
| SF-36 MCS | 49.0±0.6a | 40.3±0.9b | 35.3±1.0c | 38.4 ±0.8b | 45.7 ±1.4d | <0.001 |
| SF-36 domain | ||||||
| Physical functioning | 60.9±1.7a | 37.9±2.3b | 30.8±2.6c | 38.4±2.1b | 47.0±3.7d | <0.001 |
| Role-physical | 61.3±2.3a | 23.3±3.3b | 7.3±3.6c | 22.0±3.0b | 29.9 ±5.1b | <0.001 |
| Bodily pain | 63.4±1.3a | 40.8±1.8b | 25.5±2.0c | 35.8±1.6d | 46.8±2.8b | <0.001 |
| General health | 58.8±1.3a | 43.0±1.8b | 34.8±2.0c | 38.0±1.6c | 51.9±2.8d | <0.001 |
| Vitality | 66.0±1.2a | 50.9±1.7b | 42.7±1.9c | 47.2±1.5bc | 58.6±2.7d | <0.001 |
| Social functioning | 79.5±1.6a | 60.1±2.3b | 48.3±2.6c | 54.4±2.1bc | 73.9±3.6a | <0.001 |
| Role-emotional | 75.0±2.5a | 44.7±3.5b | 29.6±3.9c | 46.3±3.2b | 56.3±5.5b | <0.001 |
| Mental health | 73.9±1.3a | 62.2±1.8b | 54.6±2.1c | 58.0±1.7bc | 73.6±2.9a | <0.001 |
| Employed participants | Low PtGA/low MDGA (n=82) | Mod PtGA/mod MDGA (n=40) | High PtGA/high MDGA (n=23) | High PtGA/low MDGA (n=24) | Low PtGA/high MDGA (n=17) | P values |
| Absenteeism | 5.3±2.0a | 13.0±2.8ab | 18.7±3.7bc | 3.9±3.6ab | 5.9±4.2abc | 0.006 |
| Presenteeism | 20.9±2.8a | 45.5±3.9b | 59.6±5.2c | 46.6±5.1bc | 29.4±6.0a | <0.001 |
| Work productivity loss | 23.9±3.0a | 49.6±4.3b | 66.3±5.6c | 47.8±5.6b | 30.0±6.5a | <0.001 |
Values represent estimated marginal means and SEs. Analysis of covariance adjusted for age, sex, disease duration, irreversible articular damage and fibromyalgia. All pairwise comparisons are Benjamini-Hochberg corrected; values in a row not sharing subscript letters denote subgroups whose averages differ significantly.
HAQ-DI, Health Assessment Questionnaire Disability Index; MCS, Mental component summary; MDGA, physician global assessment of disease activity; PCS, physical component summary; PHQ-9, nine-item Patient Health Questionnaire; PtGA, patient global assessment of disease activity; SF-36, Short Form 36 Health Survey; VAS, visual analogue scale.