HLA-E allelic and genotypic frequencies and MAF in patients with HLA-B27 AS and HLA-B27 unaffected controls
| HLA-B27 Portuguese patients with AS | HLA-B27 Portuguese unaffected controls | ||||||
| Alleles | FAs | Fc | P values | pCA | Bonferroni | OR (95% CI) | |
| E*01:01:01 | 0.65 | 0.62 | 0.38 | 1.14 (0.87 to 1.48) | |||
| E*01:03:01 | 0.10 | 0.12 | 0.41 | 0.82 (0.55 to 1.24) | |||
| E*01:03:02 | 0.25 | 0.26 | 0.76 | 0.95 (0.70 to 1.27) | |||
| Genotypes | |||||||
| E*01:01:01/E*01:01:01 | 0.41 | 0.33 | 0.08 | 1.41 (0.97 to 2.07) | |||
| E*01:01:01/E*01:03:01 | 0.12 | 0.21 | 0.01 | 0.01 | 0.51 (0.31 to 0.85) | ||
| E*01:01:01/E*01:03:02 | 0.35 | 0.37 | 0.85 | 0.95 (0.65 to 1.39) | |||
| E*01:03:01/E*01:03:01 | 0.00 | 0.00 | 0.48 | NA | |||
| E*01:03:01/E*01:03:02 | 0.08 | 0.03 | 0.06 | 2.40 (1.02 to 5.69) | |||
| E*01:03:02/E*01:03:02 | 0.04 | 0.06 | 0.21 | 0.56 (0.23 to 1.35) | |||
| SNP | Alleles | AS MAF | C MAF | P values | pCA | Bonferroni | OR (95% CI) |
| rs1059510 | T/C | 0.24 | 0.26 | 0.10 | 0.08 | 0.90 (0.67 to 1.20) | |
| rs1264457 | G/A | 0.36 | 0.38 | 0.65 | 0.64 | 0.91 (0.70 to 1.18) | |
| SNP | Genotypes | FAs | Fc | P values | pCA | Bonferroni | OR (95% CI) |
| rs1059510 | CC | 0.54 | 0.54 | 1.00 | 0.98 (0.69 to 1.41) | ||
| CT | 0.44 | 0.39 | 0.31 | 1.22 (0.85 to 1.75) | |||
| TT | 0.02 | 0.07 | 0.03 | 0.06 | 0.35 (0.13 to 0.89) | ||
| rs1264457 | AA | 0.41 | 0.34 | 0.09 | 1.38 (0.96 to 2.00) | ||
| AG | 0.46 | 0.57 | 0.02 | 0.045 | 0.65 (0.45 to 0.93) | ||
| GG | 0.12 | 0.09 | 0.31 | 1.39 (0.78 to 2.46) |
| SNP | Alleles | AS MAF | C MAF | P values | pCA | Bonferroni | OR (95% CI) |
| rs1059510 | T/C | 0.44 | 0.39 | 0.10 | 0.08 | 1.21 (0.97 to 1.51) | |
| rs1264457 | G/A | 0.45 | 0.44 | 0.65 | 0.64 | 1.06 (0.84 to 1.32) | |
| Genotypes | FAs | Fc | P values | pCA | Bonferroni | OR (95% CI) | |
| rs1059510 | CC | 0.27 | 0.36 | 0.02 | 0.03 | 0.65 (0.47 to 0.92) | |
| CT | 0.58 | 0.49 | 0.02 | 0.04 | 1.45 (1.06 to 1.97) | ||
| TT | 0.15 | 0.15 | 1.00 | 1 (0.65 to 1.55) | |||
| rs1264457 | AA | 0.32 | 0.31 | 0.80 | 1.04 (0.75 to 1.47) | ||
| AG | 0.44 | 0.49 | 0.26 | 0.83 (0.61 to 1.14) | |||
| GG | 0.23 | 0.20 | 0.27 | 1.24 (0.85 to 1.81) |
AS, ankylosing spondylitis; AS MAF, minor allele frequency in AS patient group; Bonferroni, Bonferroni correction; C MAF, minor allele frequency in control group; FAs, patient group frequency; Fc, control group frequency; NA, not applicable; P values, Fisher’s exact test; pCA, Cochrane-Armitage test of trend; SNP, single nucleotide polymorphism.