Table 2

HLA-E allelic and genotypic frequencies and MAF in patients with HLA-B27 AS and HLA-B27 unaffected controls

HLA-B27 Portuguese patients with ASHLA-B27 Portuguese unaffected controls
Alleles FAs Fc P values pCA Bonferroni OR (95% CI)
E*01:01:01 0.650.620.381.14 (0.87 to 1.48)
E*01:03:01 0.100.120.410.82 (0.55 to 1.24)
E*01:03:02 0.250.260.760.95 (0.70 to 1.27)
Genotypes
E*01:01:01/E*01:01:01 0.410.330.081.41 (0.97 to 2.07)
E*01:01:01/E*01:03:01 0.120.210.010.010.51 (0.31 to 0.85)
E*01:01:01/E*01:03:02 0.350.370.850.95 (0.65 to 1.39)
E*01:03:01/E*01:03:01 0.000.000.48NA
E*01:03:01/E*01:03:02 0.080.030.062.40 (1.02 to 5.69)
E*01:03:02/E*01:03:02 0.040.060.210.56 (0.23 to 1.35)
SNP Alleles AS MAF C MAF P values pCA Bonferroni OR (95% CI)
rs1059510T/C0.240.260.100.080.90 (0.67 to 1.20)
rs1264457G/A0.360.380.650.640.91 (0.70 to 1.18)
SNP Genotypes FAs Fc P values pCA Bonferroni OR (95% CI)
rs1059510CC0.540.541.000.98 (0.69 to 1.41)
CT0.440.390.311.22 (0.85 to 1.75)
TT0.020.070.030.060.35 (0.13 to 0.89)
rs1264457AA0.410.340.091.38 (0.96 to 2.00)
AG0.460.570.020.0450.65 (0.45 to 0.93)
GG0.120.090.311.39 (0.78 to 2.46)
SNP Alleles AS MAF C MAF P values pCA Bonferroni OR (95% CI)
rs1059510T/C0.440.390.100.081.21 (0.97 to 1.51)
rs1264457G/A0.450.440.650.641.06 (0.84 to 1.32)
Genotypes FAs Fc P values pCA Bonferroni OR (95% CI)
rs1059510CC0.270.360.020.030.65 (0.47 to 0.92)
CT0.580.490.020.041.45 (1.06 to 1.97)
TT0.150.151.001 (0.65 to 1.55)
rs1264457AA0.320.310.801.04 (0.75 to 1.47)
AG0.440.490.260.83 (0.61 to 1.14)
GG0.230.200.271.24 (0.85 to 1.81)
  • AS, ankylosing spondylitis; AS MAF, minor allele frequency in AS patient group; Bonferroni, Bonferroni correction; C MAF, minor allele frequency in control group; FAs, patient group frequency; Fc, control group frequency; NA, not applicable; P values, Fisher’s exact test; pCA, Cochrane-Armitage test of trend; SNP, single nucleotide polymorphism.