Variable | MDD cohort(n=403 932) | General population(n=5 339 399) | P values |
Age | <0.0001 | ||
Median (IQR) years* | 36.6 (24.0) | 35.5 (27.7) | |
Sex | <0.0001 | ||
Females† | 40 749 (65.1%) | 2 648 590 (49.6%) | |
Obesity status | <0.0001 | ||
BMI<30 kg/m2 | 156 437 (38.7%) | 2 231 430 (41.8%) | |
BMI≥30 kg/m2 | 33 021 (8.2%) | 369 156 (6.9%) | |
Missing‡ | 214 474 (53.1%) | 2 738 813 (51.3%) | |
Smoking status | <0.0001 | ||
Current | 105 256 (26.1%) | 1 004 206 (18.8%) | |
Ex-smoker | 32 481 (8.0%) | 474 452 (8.9%) | |
Never | 187 864 (46.5%) | 2 711 850 (50.8%) | |
Missing | 78 331 (19.4%) | 1 148 891 (21.5%) | |
Charlson comorbidity index§ | <0.0001 | ||
0 | 314 913 (78.0%) | 4 339 935 (81.3%) | |
1 | 64 856 (16.1%) | 637 332 (11.9%) | |
2 | 11 864 (2.9%) | 139 174 (2.6%) | |
3 | 4270 (1.1%) | 52 177 (1.0%) | |
≥4 | 8029 (2.0%) | 170 781 (3.2%) | |
Antidepressant use | <0.0001 | ||
Users | 356 493 (88.3%) | 804 444 (15.1%) | |
Non-users | 47 439 (11.7%) | 4 534 955 (84.9%) |
Values show the number (per cent) of patients with a given characteristic.
* Median age in all patients before exclusion—MDD: 36.5 (23.8); General population: 35.1 (29.0).
† Sex (%) in all patients before exclusion—MDD: 65.3% females; General population: 51.4% females.
‡ BMI—represented here as baseline data before multiple imputation.
§ Higher=more severe or greater number of medical comorbidities.
BMI, body mass index; MDD, major depressive disorder.