Clinical practice guidelines in systemic sclerosis: where do we stand?
| Domain (n) | Author and year | Level of evidence10 |
| Patients (0) | No clinical practice guidelines were included. | |
| Heart (3) | Avouac et al, 201418 | S2 |
| Bissell et al, 201719 | S2 | |
| Mavrogeni et al, 201620 | S2 | |
| Malignancy (1) | Lazzaroni et al, 201721 | S2 |
| Vascular and ulcers (6) | Baron et al, 201422 | S2 |
| Fujimoto et al, 201623 | S2 | |
| Hughes et al, 201524 | S2 | |
| Pistorius et al, 201225 | S1 | |
| Maverakis et al, 201426 | S2 | |
| Cutolo et al, 201727 | S1 | |
| Gastrointestinal (3) | Alantar et al, 201128 | S2 |
| Baron et al, 201029 | S1 | |
| Hansi et al, 201430 | S2 | |
| Renal (1) | Lynch et al, 201631 | S1 |
| Interstitial lung disease (0) | No clinical practice guidelines were included. | |
| Pulmonary arterial hypertension (2) | Galiè et al, 201632 | S3 |
| Khanna et al, 201333 | S3 | |
| Diagnosis (1) | Knobler et al, 201734 | S1 |
| Contribution of healthcare providers (0) | No clinical practice guidelines were included. | |
| Treatment (5) | Kowal-Bielecka et al, 201735 | S3 |
| Denton et al, 20166 | S2 | |
| Sampaio-Barros et al, 201336 | S2 | |
| Distler et al, 201137 | S2 | |
| Knobler et al, 201438 | S2 | |
| Haematopoietic stem cell transplantation (3) | Rodrigues et al, 201339 | S2 |
| Saccardi et al, 200440 | S2 | |
| Farge et al, 201741 | S2 | |
| Clinical trials (2) | Khanna et al, 201542 | S3 |
| Khanna et al, 201043 | S1 | |
| Juvenile (1) | Pain et al, 201644 | S3 |
Level of evidence: Amendment of the ‘S-class’ classification is used to describe the degree of systematic development of guidelines and thus to identify their level of evidence, by the German Association of the Scientific Medical Societies Guidance Manual and Rules for Guideline Development:10 category S3: evidence-based and consensus-based guideline, based on a representative committee, systematic review andsynthesis of evidence (highest level of evidence); category S2: evidence-based or consensus-based guideline, based on either a systematic review and synthesis of evidence or a representative committee; category S1: recommendations by expert groups, based on consensus development in an informal procedure (lowest level of evidence).